Effects of Vocal Fold Nodules on Glottal Cycle Measurements Derived from High-Speed Videoendoscopy in Children.
Effects of Vocal Fold Nodules on Glottal Cycle Measurements Derived from High-Speed Videoendoscopy in Children.
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DOI：
10.1371/journal.pone.0154586
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Donohue KD
中科院分区：
文献类型：
--
作者：
Patel RR;Unnikrishnan H;Donohue KD
本研究的目的是利用高速视频内窥镜来量化儿童声带结节对振动运动的影响。我们对20名5-11岁的声带结节儿童和20名年龄和性别匹配的正常发育儿童（5-11岁）在典型音高和响度下持续发声时的振动运动差异进行了评估。从稳态高速视频中提取中膜声带点的声带位移归一化运动特征。计算了代表振动运动时空特征的12个运动学特征。计算下列运动学特征的平均值和标准差（周期到周期的可变性）：归一化峰值位移、归一化平均打开速度、归一化平均关闭速度、归一化峰值关闭速度、速度商和打开商。对有和无声带小结患儿的组间差异进行统计学分析。虽然在速度商的空间特征和标准化平均关闭速度的时间特征上，与发音正常的儿童相比，结节儿童的效应大小适中，但经Bonferroni校正后，各组之间的特征均无统计学意义。中膜性声带移位的运动学分析显示，结节儿童与正常发育儿童在声门循环的闭合期运动学上主要不同，而开放期运动学相似。较高的速度商和相似的打开相速度表明在关闭相中作用于声带的相对力更大。这些发现表明，未来的大规模研究应侧重于与声门循环关闭阶段相关的空间和时间特征，以区分有和没有声带结节的儿童的运动学。
The goal of this study is to quantify the effects of vocal fold nodules on vibratory motion in children using high-speed videoendoscopy. Differences in vibratory motion were evaluated in 20 children with vocal fold nodules (5–11 years) and 20 age and gender matched typically developing children (5–11 years) during sustained phonation at typical pitch and loudness. Normalized kinematic features of vocal fold displacements from the mid-membranous vocal fold point were extracted from the steady-state high-speed video. A total of 12 kinematic features representing spatial and temporal characteristics of vibratory motion were calculated. Average values and standard deviations (cycle-to-cycle variability) of the following kinematic features were computed: normalized peak displacement, normalized average opening velocity, normalized average closing velocity, normalized peak closing velocity, speed quotient, and open quotient. Group differences between children with and without vocal fold nodules were statistically investigated. While a moderate effect size was observed for the spatial feature of speed quotient, and the temporal feature of normalized average closing velocity in children with nodules compared to vocally normal children, none of the features were statistically significant between the groups after Bonferroni correction. The kinematic analysis of the mid-membranous vocal fold displacement revealed that children with nodules primarily differ from typically developing children in closing phase kinematics of the glottal cycle, whereas the opening phase kinematics are similar. Higher speed quotients and similar opening phase velocities suggest greater relative forces are acting on vocal fold in the closing phase. These findings suggest that future large-scale studies should focus on spatial and temporal features related to the closing phase of the glottal cycle for differentiating the kinematics of children with and without vocal fold nodules.