Spontaneous abortion:: A prospective cohort study of younger women from the general population in Denmark.: Validation, occurrence and risk determinants
Spontaneous abortion:: A prospective cohort study of younger women from the general population in Denmark.: Validation, occurrence and risk determinants
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DOI：
10.1080/00016340500494887
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发表时间：
2006-03-01
影响因子：
4.3
通讯作者：
Kjaer, SK
中科院分区：
文献类型：
--
作者：
Buss, L;Tolstrup, J;Kjaer, SK
Objective.评估自然流产的发生率，比较两种不同的数据来源。估计2年内自然流产的发生率，并检查意外自然流产风险的潜在预测因素。方法.我们使用了一项基于人群的前瞻性队列研究的采访数据，该研究包括11，088名女性，以及该队列与医院出院登记处联系的数据，将采访中报告的自然流产与登记处中确定的自然流产进行比较。根据访谈资料，我们估计了两年随访期间的自然流产率。最后，通过Logistic回归分析意外自然流产的危险因素。结果在参加研究之前，妇女共报告了654例自然流产，而登记册中发现的流产为531例。从这两个来源确定的自然流产中，80%以上是在同一年记录的。在随访期间，共有20.9%的妊娠计划进行到足月终止为自然流产。在危险因素分析中，我们发现既往自然流产、单身、从未使用口服避孕药和使用宫内节育器与随后自然流产的风险增加相关。此外，研究表明，自然流产后短的解释间隔可能会增加随后妊娠的流产风险。结论我们发现在本研究中自然流产率很高，并且通过访谈获得的信息与登记信息之间存在可接受的一致性。超过25%的自然流产仅由女性报告，这不能用错误报告的人工流产来解释，可能是早期非住院流产。我们证实，以前的自然流产的数量是一个强有力的决定因素，我们的数据也可能表明以前的避孕习惯的作用。不能排除解释间隔的长度在自然流产风险中的作用。
Objective. To assess the occurrence of spontaneous abortion, comparing two different data sources. To estimate the rate of spontaneous abortion over a 2-year period, and examine potential predictors of the risk for incident spontaneous abortion. Methods. We used interview data from a population-based prospective cohort study comprising 11,088 women and data from a linkage of the cohort with the Hospital Discharge Register to compare spontaneous abortions as reported in the interview with those identified in the register. Based on interview data, we estimated the rate of spontaneous abortion during the two-year follow-up. Finally, risk determinants for incident spontaneous abortion were analyzed by means of logistic regression. Results. A total of 654 spontaneous abortions before enrolment in the study were reported by the women compared to 531 abortions found in the register. More than 80% of the spontaneous abortions identified from both sources were recorded in the same year. During follow-up a total of 20.9% of pregnancies intended to be carried to term ended as a spontaneous abortion. In the risk factor analysis, we found that previous spontaneous abortion, being single, never having used oral contraceptives, and use of intrauterine device were associated with increased risk of subsequent spontaneous abortion. In addition, it was indicated that a short interpregnancy interval following a spontaneous abortion may confer an increased risk of abortion in the subsequent pregnancy. Conclusion. We found a high rate of spontaneous abortion in the present study and an acceptable agreement between information obtained by interview and register information. More than 25% of the spontaneous abortions were only reported by the women, and this could not be explained by erroneously reported induced abortions, and may be early, nonhospitalized abortions. We confirm that number of previous spontaneous abortions is a strong determinant, and our data may also indicate a role of previous contraceptive habits. A role of the length of interpregnancy interval in the risk of spontaneous abortion cannot be ruled out.