Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.
Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.
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DOI：
10.1161/circulationaha.118.033704
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发表时间：
2018-07-17
期刊：
影响因子：
37.8
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Goldberg IJ;Reue K;Abumrad NA;Bickel PE;Cohen S;Fisher EA;Galis ZS;Granneman JG;Lewandowski ED;Murphy R;Olive M;Schaffer JE;Schwartz-Longacre L;Shulman GI;Walther TC;Chen J
脂滴（LDs）是影响细胞和器官健康的独特和动态的细胞器。在理解这些结构如何形成，它们如何与其他细胞器相互作用，它们如何用于脂肪组织中三酰甘油（TAG）的储存以及它们如何调节脂解方面取得了很大进展。与脂肪组织和肝脏中的LD相比，我们对心脏和血管组织中LD的生物学的理解相对原始。美国国家心脏、肺和血液研究所（NHLBI）召集了一个工作组，讨论LD如何影响心血管疾病（CVD）。工作组的目标是检查LD细胞生物学的当前知识状态，包括在细胞和器官中研究它们的当前方法，并反映LD如何影响CVD的发展和进展。这篇综述总结了工作组的讨论和建议的研究领域成熟的未来的调查，这将可能提高我们的认识动脉粥样硬化和心脏功能。
Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol (TAG) in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive compared to LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute (NHLBI) convened a working group to discuss how LDs affect cardiovascular diseases (CVD). The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of CVDs. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.