PREPARATION AND NEW REACTIONS OF IMIDAZO[1,2-A]PYRIDINES
PREPARATION AND NEW REACTIONS OF IMIDAZO[1,2-A]PYRIDINES
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DOI：
10.1021/jo01018a071
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发表时间：
1965-01-01
影响因子：
3.6
通讯作者：
LOMBARDINO, JG
中科院分区：
文献类型：
--
作者：
LOMBARDINO, JG
给出了一些咪唑并[1，2-a]吡啶的简便制备方法。测定了部分杂环化合物的酸度常数、质子核磁共振光谱和紫外光谱。报道了Mannich反应在该体系中的应用，并对Mannich产物的反应进行了讨论。此外，2-甲基咪唑并[1，2-<；z]吡啶中的2-甲基参与了其他甲基取代杂环的一些典型反应。
Details for the facile preparation of some imidazo [1, 2-a] pyridines are presented. Acidity constants, proton nuclear magnetic resonance spectra, and ultraviolet spectra were determined for some members of this family of heterocyclic compounds. Application of the Mannich reaction to this system is reported and reactions of the Mannich products are discussed. In addition, the 2-methyl group in 2-methylimidazo [1, 2-< z] pyridine has been shown to participate in some reactions typical of other methyl-substituted heterocycles.