Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer
Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer
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DOI：
10.1111/j.1464-410x.2010.09804.x
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发表时间：
2011-06-01
影响因子：
4.5
通讯作者：
Tsujimura, Akira
中科院分区：
文献类型：
--
作者：
Nonomura, Norio;Takayama, Hitoshi;Tsujimura, Akira
证据等级4关于该主题已知的信息？这项研究增加了什么？一般来说，肿瘤相关巨噬细胞（TAM）对包括前列腺癌在内的肿瘤进展很重要。为了评估前列腺活检标本中肿瘤相关巨噬细胞（TAM）浸润作为前列腺癌（PCa）可能的预后因素，患者和方法使用单克隆抗体CD 68对71名用激素治疗的PCa患者进行前列腺活检标本中TAM的免疫染色therapy.center。血清前列腺特异性抗原（PSA）的中值为50.1ng/mL，TAM计数的中值为22.center。TAM较少（< 22）的患者的无复发生存率明显更好。中心点TAM计数在血清PSA（PSA）高、Gleason评分高、临床T分期高或PSA阴性者中较高（P < 0.001）。考克斯多因素分析显示TAM计数是前列腺癌激素治疗后的预后因素之一（P < 0.0001）。结论前列腺穿刺活检标本中的中心点TAM浸润是前列腺癌激素治疗后PSA失败或进展的一个有用的预测因素。
Level of Evidence 4What's known on the subject? and What does the study add?In general, tumour-associated macrophage (TAM) is important for tumour progression including prostate cancer.In this paper, we clarified the usefulness of TAM in prostate biopsy specimens for predicting prognosis after hormonal therapy.OBJECTIVEcenter dot To evaluate tumour-associated macrophage (TAM) infiltration in prostate biopsy specimens as a possible prognostic factor for prostate cancer (PCa) after hormonal therapy.PATIENTS AND METHODScenter dot Immunostaining of TAMs in prostate biopsy specimens was performed using a monoclonal antibody CD68 for 71 patients having PCa treated with hormonal therapy.center dot Six microscopic (x400) fields around the cancer foci were selected for TAM counting.RESULTScenter dot The median value of serum prostate-specific antigen (PSA) was 50.1 ng/mL, and the median TAM count was 22.center dot Recurrence-free survival was significantly better in patients with fewer TAMs (< 22) than in those with higher numbers of TAMs (>= 22) (P < 0.001).center dot TAM count was higher in those with higher serum PSA (PSA), higher Gleason score, clinical T stage or those with PSA failure. Cox multivariate analysis showed that TAM count is one of the prognostic factors for PCa treated by hormonal therapy (P < 0.0001).CONCLUSIONcenter dot TAM infiltration in prostate needle biopsy specimens is a useful predictive factor for PSA failure or progression of PCa after hormonal therapy.