An intensive psychoimmunologic study of long-surviving persons with AIDS. Pilot work, background studies, hypotheses, and methods.
An intensive psychoimmunologic study of long-surviving persons with AIDS. Pilot work, background studies, hypotheses, and methods.
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对长寿艾滋病患者进行的深入心理免疫学研究。
DOI：
10.1111/j.1749-6632.1987.tb35825.x
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发表时间：
1987
影响因子：
5.2
通讯作者：
Zich,J
中科院分区：
文献类型：
--
作者：
Solomon,GF;Temoshok,L;O'Leary,A;Zich,J
获得性免疫缺陷综合症（艾滋病）既是一种传染病，也是一种免疫失常性疾病。虽然它是一种“新”疾病，而且迄今为止还无法找到治疗方法或疫苗，但我们对传染病和免疫介导疾病的了解应该适用于艾滋病问题。此外，免疫缺陷发病机制中相互作用变量的复杂性以及随之而来的对各种感染的脆弱性强烈表明艾滋病是多因素的，并且从生物心理社会的角度可以理解。*因为艾滋病是一种免疫功能障碍疾病，通过感染和/或肿瘤形成，并且严重累及中枢神经系统，所以艾滋病特别适合心理神经免疫学方法。〜我们目前的研究重点是长期治疗艾滋病幸存者。虽然公众、艾滋病患者、甚至专业界普遍认为艾滋病总是致命的，但在艾滋病诊断后的 3、4、甚至 5 年后，仍有一小部分人仍然健康地活着，但数量在不断增加。这些人可以与艾滋病患者的平均预期寿命进行比较，艾滋病患者的平均预期寿命可能从 18 个月到短至 2 个月不等，具体取决于疾病的多种形式。在我们研究时，卡氏肺囊虫肺炎 (PCP) 占所有艾滋病患者的 60%，其导致的艾滋病死亡人数比任何其他感染都要多。大约35%的艾滋病患者患有
The Acquired Immune Deficiency Syndrome (AIDS) is both an infectious disease and one of immunologic aberration. While it is a “new” disease and one that has defied attempts to date to discover either a cure or a vaccine, our knowledge about both infectious and immunologically mediated diseases should be applicable to the AIDS problem. Further, the complexity of interacting variables in the pathogenesis of immune deficiency and consequent vulnerability to a variety of infections strongly suggests that AIDS is multifactoral’and understandable from a biopsychosociul perspective.* Because AIDS is a disease of immune dysfunction, one that manifests itself by infection and/or neoplasia, and one that critically involves the central nervous system,’AIDS is particularly amenable to a psychoneuroimmunologic appr~ ach.~ Our current research is focused on long-term survivors of AIDS. While the prevalent belief among the general public, persons with AIDS, and even the professional community is that AIDS is invariably fatal, there is a small but growing number of individuals who are alive and well 3, 4, and even 5 years after an AIDS diagnosis. Such individuals may be compared against the average life expectancy for AIDS patients, which may range from 18 months to as little as 2 months, depending on which of its many forms the disease takes. Pneumocystis carinii pneumonia (PCP), which accounted for 60% of all AIDS patients at the time of our study, is responsible for more AIDS deaths than any other infection. About 35% of AIDS patients have