Mouse Models of Alzheimer's Disease
Mouse Models of Alzheimer's Disease
复制标题
DOI：
10.1002/9780470669600.ch44
复制
发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
E. Oh;C. Lyketsos;P. Wong
中科院分区：
文献类型：
--
作者：
E. Oh;C. Lyketsos;P. Wong
阿尔茨海默病（AD）的转基因小鼠模型为我们理解AD的病理生理学做出了重大贡献。大多数模型表达在AD中观察到的两种主要病理变化中的一种或两种，淀粉样斑块和神经纤维缠结。在其他模型中，感兴趣的转基因的表达由外部对照控制，或从选择的基因座缺失。这些模型是研究AD生物学机制和评估潜在治疗方法的重要工具，并将继续为进一步了解AD做出重大贡献。
Transgenic mouse models of Alzheimer's disease (AD) have contributed significantly to our understanding of the pathophysiology of AD. Most models express either or both of the two major pathological changes seen in AD, amyloid plaques and neurofibrillary tangles. In other models, expression of the transgene of interest is controlled by an external control, or deleted from a selected locus. These models are essential tools for investigating biological mechanisms and assessing potential treatments for AD, and continue to make significant contribution towards further understanding of AD.