HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
HTLV‐1‐associated Myelopathy/Tropical Spastic Paraparesis‐like Rats by Intravenous Injection of HTLV‐1‐producing Rabbit or Human T‐Cell Line into Adult WKA Rats
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通过向成年 WKA 大鼠静脉注射产生 HTLV-1 的兔或人 T 细胞系来治疗 HTLV-1 相关脊髓病/热带痉挛性截瘫样大鼠
DOI：
10.1111/j.1349-7006.1993.tb02052.x
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
M. Miwa
中科院分区：
文献类型：
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作者：
S. Kushida;Masayuki Matsumura;Hiroko Tanaka;Y. Ami;M. Hori;Mikirou Kobayashi;K. Uchida;K. Yagami;T. Kameyama;T. Yoshizawa;H. Mizusawa;Y. Iwasaki;M. Miwa
我们将Ra‐1细胞或MT‐2细胞静脉注射到雌性成年WKA大鼠体内。注射后20 - 27个月，1 / 2的Ra - 1细胞注射WKA大鼠和3 / 8的MT - 2细胞注射WKA大鼠出现后肢痉挛性截瘫。主要神经病理表现为对称性白质变性伴脊髓单核细胞浸润，与HTLV - 1相关脊髓病/热带痉挛性截瘫（HAM/TSP）患者相似，神经根和周围神经变性。在这些HAM/TSP样大鼠的血浆和脑脊液中检测到HTLV - 1抗原抗体。注射后20个月，在其中一只大鼠的外周血单个核细胞中检测到HTLV - 1原病毒。有趣的是，F344大鼠未观察到痉挛性截瘫。
We intravenously injected Ra‐1 cells or MT‐2 cells into female adult WKA rats. Spastic paraparesis mainly in the hind‐limbs was observed in 1 out of 2 Ra‐1 cell‐injected WKA rats and in 3 out of 8 MT‐2 cell‐injected WKA rats 20 27 months after injection. The main neuropathological finding was symmetrical white matter degeneration with mononuclear cell infiltration of the spinal cord, similar to that of HTLV‐1‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, and degeneration of nerve roots and peripheral nerves. Antibodies against HTLV‐1 antigens were detected in plasma and cerebrospinal fluid from these HAM/TSP‐like rats. HTLV‐1 provirus was detected from the peripheral blood mononuclear cells of one of these rats 20 months after injection. Interestingly, spastic paraparesis was not observed in F344 rats.