Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: No correlation with fatigue and sleepiness
Orexin A (hypocretin-1) levels are not reduced while cocaine/amphetamine regulated transcript levels are increased in the cerebrospinal fluid of patients with multiple sclerosis: No correlation with fatigue and sleepiness
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DOI：
10.1016/j.jns.2011.04.024
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发表时间：
2011-08-15
影响因子：
4.4
通讯作者：
Ghatei, Mohammad
中科院分区：
文献类型：
--
作者：
Constantinescu, Cris S.;Niepel, Graham;Ghatei, Mohammad
背景：疲劳和睡眠障碍是多发性硬化（MS）的常见特征。我们的目标是确定脑脊液中食欲素A的水平，（hypocretin-1），一种参与睡眠的下丘脑肽，在MS患者中，并将它们与疲劳、嗜睡和可卡因和安非他明调节转录物（CART）水平相关，CART是另一种调节代谢的神经肽，具有更广泛的神经系统分布。研究对象为接受腰椎穿刺的MS（n = 34）、其他炎性（n = 24）或非炎性（n = 42）神经系统疾病的连续性患者。结果：炎性疾病患者脑脊液中Orexin A含量轻度降低，但Orexin A含量与CART含量无明显相关性。MS中没有食欲素A缺乏的证据，尽管与非炎性神经系统疾病相比，食欲素A的减少趋势不显著（p=0.06）。与非炎性疾病组相比，MS中的CART水平增加（p=0.03）。CSF中食欲素A和CART，疲劳和hypersomnolence.Conclusions水平之间没有显着的相关性：脑脊液食欲素A是减少CNS炎症性疾病比MS，在那里它显示出减少的趋势，但不相关的显着CART或与措施的疲劳和hypersomnolence。(C)出版社：Elsevier B. V.
Background: Fatigue and sleep disturbance are common features of multiple sclerosis (MS). Our objectives were to determine cerebrospinal fluid levels of orexin A (hypocretin-1), a hypothalamic peptide involved in sleep, in patients with MS, and correlate them with fatigue, sleepiness, and levels of cocaine and amphetamine regulated transcript (CART) another neuropeptide regulating metabolism with wider nervous system distribution.Methods: Consecutive patients with MS (n = 34), other inflammatory (n = 24) or non-inflammatory (n = 42) neurological diseases, undergoing lumbar puncture were investigated. Orexin and CART were measured by RIA by investigators unaware of the patients' diagnosis.Results: Orexin A was slightly decreased in the cerebrospinal fluid of patients with inflammatory disease. There was no evidence of orexin A deficiency in MS, although there was a non-significant trend toward a decrease compared to non-inflammatory neurological diseases (p=0.06). CART levels were increased in MS compared to the non-inflammatory disease group (p=0.03). There were no significant correlations between CSF levels of orexin A and CART, fatigue, and hypersomnolence.Conclusions: Cerebrospinal fluid orexin A is decreased in CNS inflammatory diseases other than MS, where it shows a trend toward reduction, but does not correlate significantly with CART or with measures of fatigue and hypersomnolence. (C) 2011 Published by Elsevier B.V.