Acute and residual effects of marijuana in humans
Acute and residual effects of marijuana in humans
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DOI：
10.1016/s0091-3057(97)00386-9
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发表时间：
1998-08-01
影响因子：
3.6
通讯作者：
Pickworth, WB
中科院分区：
文献类型：
--
作者：
Fant, RV;Heishman, SJ;Pickworth, WB
大麻仍然是美国最常滥用的非法药物，因为许多人在晚上和周末滥用大麻，然后第二天去上班或上学，需要对大麻的残留影响进行更多的研究。目前的研究试图检查急性和残留的主观，生理和性能的影响吸烟单一大麻香烟。10名健康男性志愿者报告最近使用大麻居住在一个住宅研究病房。在三个独立的日子里，受试者根据起搏的抽吸程序吸一支含有0%、1.8%或3.6% Δ（9）-四氢大麻酚（THC）的NIDA大麻香烟。在吸烟前、当天吸烟后五次和第二天早上三次收集主观、生理和性能指标。受试者在两种活性剂量的大麻后报告了强烈的主观效果，在3.5小时内恢复到基线水平。活性剂量给药后，心率增加，瞳孔对光反射降低，当天恢复至基线。一项新的发现是，吸食大麻会严重降低平稳追踪的眼球追踪能力。虽然发现大麻对主观和生理测量以及对平稳追踪眼动跟踪性能的强烈急性影响，但在给药后的第二天没有明显影响，这表明吸食单一大麻香烟的残余影响很小。(C)1998年爱思唯尔科学公司
Marijuana continues to be the most commonly abused illicit drug in the United States, Because many people abuse marijuana during the evening and on weekends and then go to work or school the next day, more research is needed on the residual effects of marijuana. The current study sought to examine both acute and residual subjective, physiologic, and performance effects of smoking a single marijuana cigarette. Ten healthy male volunteers who reported recent use of marijuana resided, on a residential research ward. On three separate days, subjects smoked one NIDA marijuana cigarette containing either 0%, 1.8%, or 3.6% Delta(9)-tetrahydrocannabinol (THC) according to a paced puffing procedure. Subjective, physiologic, and performance measures were collected prior to smoking, five times following smoking on that day, and three times on the following morning. Subjects reported robust subjective effects following both active doses of marijuana, which returned to baseline levels within 3.5 h. Heart rate increased and the pupillary light reflex decreased following active dose administration with return to baseline on that day. A new finding was that marijuana smoking acutely produced decrements in smooth pursuit eye tracking. Although robust acute effects of marijuana were found on subjective and physiological measures, and on smooth pursuit eye tracking performance, no effects were evident the day following administration, indicating that the residual effects of smoking a single marijuana cigarette are minimal. (C) 1998 Elsevier Science Inc.