HOW MHC CLASS-II MOLECULES WORK - PEPTIDE-DEPENDENT COMPLETION OF PROTEIN FOLDING
HOW MHC CLASS-II MOLECULES WORK - PEPTIDE-DEPENDENT COMPLETION OF PROTEIN FOLDING
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DOI：
10.1016/0167-5699(92)90131-p
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发表时间：
1992-02-01
期刊：
影响因子：
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通讯作者：
GERMAIN, RN
中科院分区：
文献类型：
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作者：
SADEGHNASSERI, S;GERMAIN, RN
现在清楚的是，肽在稳定MHC II类分子的结构中起关键作用。在这里，舍赫拉扎德·萨德格-纳塞里和罗恩·热尔曼提出，新合成的MHC II类分子，实际上是I类分子，表现得像部分折叠的蛋白质，肽作为MHC多肽结构的替代部分，是完成构象成熟所必需的。
It is now clear that peptides play a key role in stabilizing the structure of MHC class II molecules. Here, Scheherazade Sadegh-Nasseri and Ron Germain propose that newly synthesized MHC class II, and indeed class I, molecules behave like partially folded proteins, with peptides acting as a surrogate portion of the MHC polypeptide structure that is necessary for completion of conformational maturation.