Dissociation of human caudate nucleus activity in spatial and nonspatial working memory: an event-related fMRI study
Dissociation of human caudate nucleus activity in spatial and nonspatial working memory: an event-related fMRI study
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DOI：
10.1016/s0926-6410(99)00010-5
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发表时间：
1999-07-16
期刊：
影响因子：
--
通讯作者：
D'Esposito, M
中科院分区：
文献类型：
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作者：
Postle, BR;D'Esposito, M
我们采用了一种新的事件相关fMRI设计和分析技术来探索尾状核对空间和非空间工作记忆的贡献。延迟反应任务的空间条件显示，与不需要反应的探测刺激相比，当延迟时间紧跟在需要显性运动反应的探测刺激之前时，六个受试者中有四个的记忆激活程度更高。这种影响在额叶或顶叶皮质区域中看不到，在六名受试者中只有一名在形式上相同的目标条件下在尾状核看到了这种影响。我们假设这种活动模式代表了空间依赖的运动准备。第二个实验证实了这一假设：在具有空间和运动记忆要求的任务中，尾状核的延迟周期活动表现出更大的时间依赖性，而在具有相同反应偶发事件的可比非空间任务中。这些结果表明，在空间和非空间工作记忆之间存在一个重要的皮层下分离场所，人类尾状核在整合空间编码的助记信息和指导行为的运动准备中发挥了作用。(C)1999 Elsevier Science B.V.保留所有权利。
We employed a novel event-related fMRI design and analysis technique to explore caudate nucleus contributions to spatial and nonspatial working memory. The spatial condition of a delayed-response task revealed greater mnemonic activation in four of six subjects when the delay period preceded immediately a probe stimulus requiring an overt motor response, as contrasted with a probe requiring no response. This effect was not seen in frontal or parietal cortical areas, and was seen in the caudate nucleus in a formally identical object condition in just one of six subjects. We hypothesized that this pattern of activity represented spatially dependent motor preparation. A second experiment confirmed this hypothesis: delay-period activity of the caudate nucleus showed greater time dependence in a task that featured spatial and motoric memory demands than in a comparable nonspatial task that featured the same response contingencies. These results suggest an important subcortical locus of the dissociation between spatial and nonspatial working memory, and a role for the human caudate nucleus in the integration of spatially coded mnemonic information with motor preparation to guide behavior. (C) 1999 Elsevier Science B.V. All rights reserved.