Infrared laser-spectroscopic analysis of 14NO and 15NO in human breath
Infrared laser-spectroscopic analysis of 14NO and 15NO in human breath
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DOI：
10.1007/s00340-009-3423-1
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发表时间：
2009-05-01
影响因子：
2.1
通讯作者：
Muertz, M.
中科院分区：
文献类型：
--
作者：
Heinrich, K.;Fritsch, T.;Muertz, M.
我们报告监测一氧化氮（NO）的痕迹，在人体呼吸通过红外腔泄漏光谱。用5 μ m波长的CO边带激光器和两个高反射率镜（R=99.98%）的光学腔，最小可探测吸收为2 × 10 ~（-10）cm ~（-1）Hz ~（1/2）。这使得光谱分析罕见的NO同位素具有前所未有的灵敏度。应用于同时在线检测（NO）-N-14和（NO）-N-15在呼吸样品中收集在鼻腔中的首次描述。我们实现了鼻（NO）-N-15（积分时间：70秒）的噪声等效检测限为万亿分之七。
We report on monitoring of nitric oxide (NO) traces in human breath via infrared cavity leak-out spectroscopy. Using a CO sideband laser near 5 mu m wavelength and an optical cavity with two high-reflectivity mirrors (R=99.98%), the minimum detectable absorption is 2x10(-10) cm(-1) Hz(1/2). This allows for spectroscopic analysis of rare NO isotopologues with unprecedented sensitivity. Application to simultaneous online detection of (NO)-N-14 and (NO)-N-15 in breath samples collected in the nasal cavity is described for the first time. We achieved a noise-equivalent detection limit of 7 parts per trillion for nasal (NO)-N-15 (integration time: 70 s).