B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria.
B cell intrinsic expression of IFNλ receptor suppresses the acute humoral immune response to experimental blood-stage malaria.
复制标题
DOI：
10.1080/21505594.2020.1768329
复制
发表时间：
2020-12
期刊：
影响因子：
5.2
通讯作者：
Liles WC
中科院分区：
文献类型：
--
作者：
Hahn WO;Pepper M;Liles WC
抗体在宿主对血液期疟疾感染的反应中起着关键的保护作用。细胞因子在形成对血液期疟疾的抗体反应中的作用尚不清楚。干扰素λ（IFNλ）是一种III型干扰素，是在血液阶段疟疾感染期间早期产生的细胞因子，其在疟疾感染期间具有未知的生理作用。我们证明，B细胞固有的IFNλ信号抑制急性抗体反应，急性浆母细胞反应，并阻碍急性寄生虫清除在初级血液阶段疟疾感染。我们的研究结果表明，在宿主对实验性疟疾的应答中，B细胞内在IFNλ信号在启动体液免疫应答中的作用以前未被认识。
Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear. Interferon lambda (IFNλ), a type III interferon, is a cytokine produced early during blood-stage malaria infection that has an unknown physiological role during malaria infection. We demonstrate that B cell-intrinsic IFNλ signals suppress the acute antibody response, acute plasmablast response, and impede acute parasite clearance during a primary blood-stage malaria infection. Our findings demonstrate a previously unappreciated role for B cell intrinsic IFNλ-signaling in the initiation of the humoral immune response in the host response to experimental malaria.