PSYCHIATRIC MANIFESTATIONS OF SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICAL-FEATURES, SYMPTOMS, AND SIGNS OF CENTRAL-NERVOUS-SYSTEM ACTIVITY IN 43 PATIENTS
PSYCHIATRIC MANIFESTATIONS OF SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICAL-FEATURES, SYMPTOMS, AND SIGNS OF CENTRAL-NERVOUS-SYSTEM ACTIVITY IN 43 PATIENTS
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DOI：
10.1097/00005792-199407000-00005
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发表时间：
1994-07-01
期刊：
影响因子：
1.6
通讯作者：
GENTIL, V
中科院分区：
文献类型：
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作者：
MIGUEL, EC;PEREIRA, RMR;GENTIL, V
精神异常是系统性红斑狼疮（SLE）的常见表现。据报道，SLE 患者精神症状的患病率存在显着差异（从 17% 到 75%）(13, 37)。这种广泛的范围可以通过各种研究中采用的不同方法来解释，例如评估技术和受试者选择的差异 (32, 36, 62)，以及中枢神经系统 (CNS) 中 SLE 神经精神表现缺乏可靠的标志物和公认的诊断标准 (6, 24)。 SLE 患者的精神疾病可能主要是由于中枢神经系统中的 SLE 活动所致，也可能是由 SLE 并发症引起，例如感染、尿毒症、电解质异常或其治疗（例如皮质类固醇）。此外，系统性红斑狼疮患者的精神异常可能继发于原发性精神疾病（例如双相情感障碍）或与慢性和潜在致命疾病（例如适应障碍）相关的心理压力。各有症状
Psychiatric abnormalities are a common manifestation of systemic lupus erythematosus (SLE). Substantial differences in the prevalence of psychiatric symptoms in patients with SLE (from 17% to 75%) have been reported (13, 37). This wide range can be accounted for by disparate methods em-ployed in various studies, such as differences in assessment techniques and selection of subjects (32, 36, 62), and by the absence of a reliable marker and well-accepted diagnostic criteria for neuropsychi-atric manifestation of SLE in the central nervous system (CNS)(6, 24). Psychiatric disorders in patients with SLE may be due primarily to activity of SLE in the CNS or may result from complications of SLE, such as infection, uremia, electrolyte abnormalities, or its treatment, such as corticosteroids. Also, psychiatric abnormalities in patients with SLE may be secondary to a primary psychiatric disorder (for example, bipolar disorder) or to psychological stress associated with a chronic and potentially lethal disease (such as adjustment disorders). Symptoms of each