Changes in Risk Behavior Among HIV-Positive Patients During Their First Year of Antiretroviral Therapy in Cape Town South Africa
Changes in Risk Behavior Among HIV-Positive Patients During Their First Year of Antiretroviral Therapy in Cape Town South Africa
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DOI：
10.1007/s10461-008-9473-2
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发表时间：
2009-12-01
影响因子：
4.4
通讯作者：
Kendall, Carl
中科院分区：
文献类型：
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作者：
Eisele, Thomas P.;Mathews, Catherine;Kendall, Carl
我们探讨性风险行为的变化，在第一年的抗逆转录病毒治疗（ART）在开普敦南非的一个队列的患者开始在五个公共设施在2006年的治疗，并再次1年后（时间1和时间2）。同期措施的无保护性行为也获得了2个横断面样本的艾滋病毒阳性患者等待开始ART出席同一设施。接受抗逆转录病毒治疗的患者最后一次性行为时无保护性行为的发生率在一年后从基线的44.7%-23.2%显著下降，无论其伴侣状态如何。控制混杂因素后，观察到的减少无保护的性行为之间的ART队列是非常显着的2个横断面样本的患者在时间1和时间2等待启动ART。研究结果表明，这是至关重要的，开始积极预防，以减少危险的性行为开始之前，在这种设置的ART。
We explore changes in sexual risk behaviour over the first year of antiretroviral therapy (ART) among a cohort of patients in Cape Town South Africa initiating treatment in five public facilities in 2006 and again 1 year later (Time 1 and Time 2). Contemporaneous measures of unprotected sex were also obtained from 2 cross-sectional samples of HIV-positive patients waiting to start ART attending the same facilities. Unprotected sex at last sex among patients on ART decreased significantly from a baseline of 44.7-23.2% one year later, regardless of partner status. After controlling for confounding factors, the observed decrease in unprotected sex among the ART cohort was highly significant in relation to the 2 cross-sectional samples of patients at Time 1 and Time 2 waiting to initiate ART. Findings suggest it is critical to start positive prevention to decrease risky sexual behavior prior to the start of ART within this setting.