Dual growth factor-induced angiogenesis in vivo using hyaluronan hydrogel implants
Dual growth factor-induced angiogenesis in vivo using hyaluronan hydrogel implants
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DOI：
10.1016/j.biomaterials.2005.09.035
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发表时间：
2006-03-01
期刊：
影响因子：
14
通讯作者：
Prestwich, GD
中科院分区：
文献类型：
--
作者：
Peattie, RA;Rieke, ER;Prestwich, GD
交联透明质酸（HA）水凝胶预载两种细胞因子生长因子，血管内皮生长因子（VEGF）和角质形成细胞生长因子（KGF），在体内引起新的微血管生长。作为细胞外基质（ECM）的主要糖胺聚糖（GAG）组分，HA是新型仿生、生物相容性治疗材料的优良生物聚合物构建块。将HA水凝胶膜样品手术植入小鼠的耳廓中，并在植入后7或14天收获耳朵。组织学分析显示，接受植入物的各组的微血管密度明显高于接受手术但未接受植入物的对照耳（p
Crosslinked hyaluronan (HA) hydrogels preloaded with two cytokine growth factors, vascular endothelial growth factor (VEGF) and keratinocyte growth factor (KGF), were employed to elicit new microvessel growth in vivo. As a major glycosaminoglycan (GAG) component of extracellular matrix (ECM), HA is an excellent biopolymeric building block for new biomimetic, biocompatible therapeutic materials. HA hydrogel film samples were surgically implanted in the ear pinnae of mice, and the ears were harvested at 7 or 14 days post-implantation. Histologic analysis showed that each of the groups receiving an implant demonstrated significantly more microvessel density than control ears undergoing surgery but receiving no implant (p