DNA double-strand breaks as drivers of neural genomic change, function, and disease
DNA double-strand breaks as drivers of neural genomic change, function, and disease
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DOI：
10.1016/j.dnarep.2018.08.019
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发表时间：
2018-11-01
期刊：
影响因子：
3.8
通讯作者：
Schwer, Bjoern
中科院分区：
文献类型：
--
作者：
Alt, Frederick W.;Schwer, Bjoern
大约20年前的早期工作涉及神经元发育中DNA双链断裂（DSB）的形成和修复。从DSB在增殖的神经祖细胞和成熟的非分裂神经元中的最近研究中出现的发现表明DSB在脑生理学、衰老、癌症、精神病和神经退行性疾病中的重要作用。我们提供了一些调查结果的概述，并推测未来可能会发生什么。
Early work from about two decades ago implicated DNA double-strand break (DSB) formation and repair in neuronal development. Findings emerging from recent studies of DSBs in proliferating neural progenitors and in mature, non-dividing neurons suggest important roles of DSBs in brain physiology, aging, cancer, psychiatric and neurodegenerative disorders. We provide an overview of some findings and speculate on what may lie ahead.