pH-dependent binding constants for the inhibition of thrombin by transition state analogs.
pH-dependent binding constants for the inhibition of thrombin by transition state analogs.
复制标题
过渡态类似物抑制凝血酶的 pH 依赖性结合常数。
DOI：
10.1007/978-1-4899-2418-6_6
复制
发表时间：
1993
影响因子：
--
通讯作者：
Metternich,R
中科院分区：
文献类型：
--
作者：
Philipp,M;Niua,LH;DeSoyza,T;Claeson,G;Metternich,R
过渡态类似物通过提供反应过程中酶状态的模型，为酶催化过程提供了一个独特的视角。研究这些抑制剂结合的pH依赖性可以更好地理解催化过程，特别是当这些依赖性与底物和其他抑制剂相比较时。
Transition state analogs provide a unique view into the course of enzyme catalysis by providing a model of the enzyme’s state during the reaction. Studying the pH dependencies of binding by such inhibitors promises a better understanding of the course of catalysis, especially when these dependencies are compared to those of substrates and other inhibitors.