LOCALIZATION OF THE TELOMERIC (TTAGGG)N SEQUENCE IN CHICKEN (GALLUS-DOMESTICUS) CHROMOSOMES
LOCALIZATION OF THE TELOMERIC (TTAGGG)N SEQUENCE IN CHICKEN (GALLUS-DOMESTICUS) CHROMOSOMES
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DOI：
10.1159/000133630
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
SCHMID, M
中科院分区：
文献类型：
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作者：
NANDA, I;SCHMID, M
利用FISH技术研究了真核生物端粒（TTAGGG）n序列在鸡中期染色体中的分布。除了预期的端粒位置，间质以及着丝粒位置的（TTAGGG）n重复观察几个大染色体。微染色体显示三种离散的标记模式与此重复。鸡染色体中端粒相关序列的这种极端不同的分布的意义可能在于指出在核型进化过程中可能发生的结构事件。
The distribution of the highly conserved eukaryotic telomeric (TTAGGG)n sequence was investigated in chicken metaphase chromosomes using the FISH technique. Besides the expected telomeric locations, interstitial as well as centromeric locations of the (TTAGGG)n repeat were observed on several macrochromosomes. The microchromosomes display three discrete patterns of labeling with this repeat. The significance of this extreme-different distribution of the telomeric related sequence in chicken chromosomes may lie in pointing to structural events that might have occurred during the process of karyotype evolution.