Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability
Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability
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DOI：
10.1016/j.atherosclerosis.2010.05.022
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发表时间：
2010-09-01
期刊：
影响因子：
5.3
通讯作者：
Calder, Philip C.
中科院分区：
文献类型：
--
作者：
Cawood, Abbie L.;Ding, Ren;Calder, Philip C.
目的：研究n-3多不饱和脂肪酸（PUFA）纳入动脉粥样硬化斑块和斑块炎症和stability.Methods和结果：等待颈动脉内膜切除术（n=121）的患者随机消费控制胶囊或n-3 PUFA乙酯胶囊，直到手术（中位数21天）。测定血浆和颈动脉斑块磷脂的脂肪酸组成、斑块特征和炎症基因的表达。二十碳五烯酸（EPA）的比例较高（P
Objective : To examine n-3 polyunsaturated fatty acid (PUFA) incorporation into atherosclerotic plaques and the association with plaque inflammation and stability.Methods and results : Patients awaiting carotid endarterectomy (n=121) were randomised to consume control capsules or n-3 PUFA ethyl ester capsules until surgery (median 21 days). The fatty acid compositions of plasma and carotid plaque phospholipids, plaque features, and expression of inflammatory genes were determined. The proportion of eicosapentaenoic acid (EPA) was higher (P