Selective Activation of Neuronal Targets With Sinusoidal Electric Stimulation
Selective Activation of Neuronal Targets With Sinusoidal Electric Stimulation
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DOI：
10.1152/jn.00551.2010
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发表时间：
2010-11-01
影响因子：
2.5
通讯作者：
Fried, Shelley I.
中科院分区：
文献类型：
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作者：
Freeman, Daniel K.;Eddington, Donald K.;Fried, Shelley I.
Freeman DK，Eddington DK，Rizzo JF，Fried SI.用正弦电刺激选择性激活神经元靶点。神经生理学杂志104：2778-2791，2010年。首次发表于2010年9月1日; doi：10.1152/jn.00551.2010。电刺激中枢神经系统正在评估作为一种治疗方式的各种神经，精神和感觉障碍。尽管在一些应用中取得了相当大的成功，但现有的刺激技术对哪些细胞类型或神经元亚结构被刺激激活几乎没有控制。更精确地控制神经元激活的能力可能会改善与这些应用相关的临床结果。在这里，我们表明，特定频率的正弦刺激可用于优先激活某些视网膜细胞类型：光感受器在5 Hz激活，双极细胞在25 Hz激活，神经节细胞在100 Hz激活。此外，低频刺激（
Freeman DK, Eddington DK, Rizzo JF, Fried SI. Selective activation of neuronal targets with sinusoidal electric stimulation. J Neurophysiol 104: 2778-2791, 2010. First published September 1, 2010; doi:10.1152/jn.00551.2010. Electric stimulation of the CNS is being evaluated as a treatment modality for a variety of neurological, psychiatric, and sensory disorders. Despite considerable success in some applications, existing stimulation techniques offer little control over which cell types or neuronal substructures are activated by stimulation. The ability to more precisely control neuronal activation would likely improve the clinical outcomes associated with these applications. Here, we show that specific frequencies of sinusoidal stimulation can be used to preferentially activate certain retinal cell types: photoreceptors are activated at 5 Hz, bipolar cells at 25 Hz, and ganglion cells at 100 Hz. In addition, low-frequency stimulation (