State of the art on food allergen immunotherapy: Oral, sublingual, and epicutaneous
State of the art on food allergen immunotherapy: Oral, sublingual, and epicutaneous
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DOI：
10.1016/j.jaci.2013.12.1040
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发表时间：
2014-02-01
影响因子：
14.2
通讯作者：
Dupont, Christophe
中科院分区：
文献类型：
--
作者：
Jones, Stacie M.;Burks, A. Wesley;Dupont, Christophe
免疫球蛋白介导的食物过敏是一个全球性的健康问题，影响着数百万人，并影响到患者生活的方方面面。制定有效的治疗策略，以加强目前严格的饮食避免抗原和可自我注射肾上腺素的实践标准，一直是研究团队、倡导团体、资助机构和患者及其家人的主要重点。通过开发包括3种主要治疗形式的过敏原特异性免疫疗法已经取得了重大进展：口服、舌下和皮肤下免疫疗法。这些疗法正处于不同的临床研究阶段，在临床结果和免疫机制的调节方面取得了一些成功，使之成为有效的治疗方法。在这里，我们回顾了这些形式的免疫疗法作为一种新兴的食物过敏治疗方法的作用，最近的进展和关注的领域。
IgE-mediated food allergy is a global health problem that affects millions of persons and affects every aspect of life for the patient. Developing effective treatment strategies to augment current practice standards of strict dietary avoidance of antigens and availability of self-injectable epinephrine has been a major focus of research teams, advocacy groups, funding agencies, and patients and their families. Significant progress has been made through the development of allergen-specific immunotherapy encompassing 3 major forms of treatment: oral, sublingual, and epicutaneous immunotherapy. These therapies are in various stages of clinical investigation, with some successes noted in clinical outcomes and modulation of immune mechanisms toward effective therapy. Here we review recent progress and areas of concern for the role of these forms of immunotherapy as an emerging treatment for food allergy.