Reconstruction of ancient molecular phylogeny
Reconstruction of ancient molecular phylogeny
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DOI：
10.1006/mpev.1996.0071
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发表时间：
1996-10-01
影响因子：
4.1
通讯作者：
Smith, TF
中科院分区：
文献类型：
--
作者：
Guigo, R;Muchnik, I;Smith, TF
当不同基因的分子序列数据被用来重建系统发育史时，常常会得到对矛盾系统发育的支持。许多数据异常（包括未识别的旁系关系）可能导致矛盾的同源性。旁系，定义为从由重复产生的基因的混合物重建系统发育树，通常没有正式包括在系统发育重建中。在这里，我们承担的任务，重建一个单一的最有可能的进化关系之间的一系列类群从一个大的明显不一致的基因树。假设基因树之间的差异可以用基因重复和随之而来的损失来解释，我们已经开发出一种方法来获得全球的重复和损失的总数量最小化，并追溯到全球基因组重复这样的个人基因重复。我们用这种方法从53个不同基因的序列中推断了16个主要高等真核生物类群之间最可能的系统发育关系，只需要假设5个独立的基因组重复事件就可以解释这些树之间的不一致。(C)出版社：Academic Press，Inc.
Support for contradictory phylogenies is often obtained when molecular sequence data from different genes is used to reconstruct phylogenetic histories. Contradictory phylogenies can result from many data anomalies including unrecognized paralogy. Paralogy, defined as the reconstruction of a phylogenetic tree from a mixture of genes generated by duplications, has generally not been formally included in phylogenetic reconstructions. Here we undertake the task of reconstructing a single most likely evolutionary relationship among a range of taxa from a large set of apparently inconsistent gene trees. Under the assumption that differences among gene trees can be explained by gene duplications, and consequent losses, we have developed a method to obtain the global phylogeny minimizing the total number of postulated duplications and losses and to trace back such individual gene duplications to global genome duplications. We have used this method to infer the most likely phylogenetic relationship among 16 major higher eukaryotic taxa from the sequences of 53 different genes, Only five independent genome duplication events need to be postulated in order to explain the inconsistencies among these trees. (C) 1996 Academic Press, Inc.