DISTRIBUTION OF GLYCINE A NEUROTRANSMITTER SUSPECT IN CENTRAL NERVOUS SYSTEM OF SEVERAL VERTEBRATE SPECIES
DISTRIBUTION OF GLYCINE A NEUROTRANSMITTER SUSPECT IN CENTRAL NERVOUS SYSTEM OF SEVERAL VERTEBRATE SPECIES
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DOI：
10.1016/0024-3205(68)90182-3
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发表时间：
1968-01-01
期刊：
影响因子：
--
通讯作者：
WERMAN, R
中科院分区：
文献类型：
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作者：
APRISON, MH;SHANK, RP;WERMAN, R
用微量化学法测定了猫、大鼠、鸽子、凯门鳄和牛蛙大脑半球、间脑、中脑、小脑、延髓、颈膨大、胸中索和腰膨大等脑区的甘氨酸含量，结果表明，延髓、颈膨大和腰膨大的甘氨酸含量是延髓头端四个脑区的3-5倍。它位于胸中脊髓和小脑的低位。一般注意到甘氨酸浓度的增加的吻尾梯度，并且在猫和大鼠中最明显。在颈部和腰部脊髓和髓质中的高甘氨酸浓度与甘氨酸在这些区域中的可能的递质功能相容。
The glycine concentration in the cerebral hemisphere, diencephalon, midbrain, cerebellum, medulla oblongata, certival enlargement, midthoracic cord, and lumbar enlargement in cat, rat, pigeon, caiman and bullfrog was measured by a specific microchemical assay.The glycine concentration was 3–5 times higher in the medulla oblongata, cervical and lumbar enlargements than in the four brain areas rostral to the medulla. It was low in the mid-thoracic spinal cord and in the cerebellum. An increasing rostrocaudal gradient in glycine concentration was generally noted and was most evident in the cat and rat.The high glycine concentration in the cervical and lumbar spinal cord and the medulla is compatible with a possible transmitter function for glycine in these areas.