Calcium Ion Channels: Roles in Infection and Sepsis Mechanisms of Calcium Channel Blocker Benefits in Immunocompromised Patients at Risk for Infection.
Calcium Ion Channels: Roles in Infection and Sepsis Mechanisms of Calcium Channel Blocker Benefits in Immunocompromised Patients at Risk for Infection.
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DOI：
10.3390/ijms19092465
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发表时间：
2018-08-21
影响因子：
5.6
通讯作者：
Weinrauch LA
中科院分区：
文献类型：
--
作者：
D'Elia JA;Weinrauch LA
免疫抑制可能由于与个体的虚弱、虚弱、疾病或治疗性医源性干预或意外有关的许多原因而发生。免疫缺陷人群中很大比例的发病率和死亡率与对抗生素反应缓慢的感染原反应不足、人群中抗生素耐药性增强以及急性炎症反应、脓毒性和感染相关死亡的患病率显著增加有关。鉴于细胞内钙离子浓度与细胞毒性和细胞死亡之间的已知关系，我们研究了目前可用的数据，这些数据将钙离子通道阻滞与免疫抑制患者中脓毒症表达的潜在降低联系起来。值得注意的是钙、钙通道、与脓毒症相关的维生素D机制和可能利用对钙通道阻滞剂敏感的通道的耐药病原体的证明之间的关系。我们注意到，脓毒症休克综合征代表了对感染的炎症反应的调节丧失，维生素D、甲状旁腺激素、成纤维细胞生长因子和klotho与脓毒症防御机制相互作用，其中钙和磷的运动是该过程的一部分。鉴于这些观察结果，我们认为进一步研究相对便宜的钙通道阻滞剂对免疫抑制人群感染的影响可能是值得的。
Immunosuppression may occur for a number of reasons related to an individual’s frailty, debility, disease or from therapeutic iatrogenic intervention or misadventure. A large percentage of morbidity and mortality in immunodeficient populations is related to an inadequate response to infectious agents with slow response to antibiotics, enhancements of antibiotic resistance in populations, and markedly increased prevalence of acute inflammatory response, septic and infection related death. Given known relationships between intracellular calcium ion concentrations and cytotoxicity and cellular death, we looked at currently available data linking blockade of calcium ion channels and potential decrease in expression of sepsis among immunosuppressed patients. Notable are relationships between calcium, calcium channel, vitamin D mechanisms associated with sepsis and demonstration of antibiotic-resistant pathogens that may utilize channels sensitive to calcium channel blocker. We note that sepsis shock syndrome represents loss of regulation of inflammatory response to infection and that vitamin D, parathyroid hormone, fibroblast growth factor, and klotho interact with sepsis defense mechanisms in which movement of calcium and phosphorus are part of the process. Given these observations we consider that further investigation of the effect of relatively inexpensive calcium channel blockade agents of infections in immunosuppressed populations might be worthwhile.
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影响因子：
13.2
作者：
ALEXIEWICZ, JM;SMOGORZEWSKI, M;MASSRY, SG
通讯作者：
MASSRY, SG
影响因子：
3.2
作者：
BUKOSKI, RD;XUE, H
通讯作者：
XUE, H
影响因子：
6.2
作者：
CHRYSOSTOMOU, A;WALKER, RG;MATHEW, TH
通讯作者：
MATHEW, TH
影响因子：
13.2
作者：
DELIA, JA;WEINRAUCH, LA;KALDANY, A
通讯作者：
KALDANY, A
影响因子：
4.8
作者：
Borahay, Mostafa A.;Kilic, Gokhan S.;Boehning, Darren
通讯作者：
Boehning, Darren