The Science behind Preparing and Responding to Pandemic Influenza: The Lessons and Limits of Science
The Science behind Preparing and Responding to Pandemic Influenza: The Lessons and Limits of Science
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DOI：
10.1093/cid/ciq007
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发表时间：
2011-01-01
影响因子：
11.8
通讯作者：
Redd, Stephen C.
中科院分区：
文献类型：
--
作者：
Schuchat, Anne;Bell, Beth P.;Redd, Stephen C.
强有力的证据基础为规划和应对战略提供了基础。对大流行防范的投资包括支持有助于早期发现、应对和控制2009年甲型H1N1流感大流行的研究。在大流行期间进行的科学调查指导了对病毒、疾病严重程度和流行病学危险因素的理解。实地调查还产生了加强抗病毒药物使用指导、确定单价甲型h1n1流感疫苗目标人群以及完善社会距离措施建议的信息。传播这一不断发展的证据基础对于维持公共卫生的可信度至关重要。出现重大争议的领域，如卫生保健工作者呼吸保护的最佳方法，往往存在证据基础上的差距。2009-2010年大流行性流感经验的许多方面为进一步研究提供了持续的机会，这将加强未来大流行性流感应对和季节性流感控制的计划。
A strong evidence base provides the foundation for planning and response strategies. Investments in pandemic preparedness included support for research that aided early detection, response, and control of the 2009 influenza A (H1N1) (pH1N1) pandemic. Scientific investigations conducted during the pandemic guided understanding of the virus, disease severity, and epidemiologic risk factors. Field investigations also produced information that strengthened guidance for the use of antivirals, identification of target populations for monovalent pH1N1 vaccine, and refinement of recommendations for social distancing measures. Communication of this evolving evidence base was important to sustaining credibility of public health. Areas where substantial controversy emerged, such as the optimal approach to respiratory protection of healthcare workers, often suffered from gaps in the evidence base. Many aspects of the 2009-2010 pandemic influenza experience provide ongoing opportunities for additional study, which will strengthen plans for future pandemic response as well as control of seasonal influenza.