VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor-Associated Transcription Repressor, Is a Putative Tumor Suppressor
VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor-Associated Transcription Repressor, Is a Putative Tumor Suppressor
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DOI：
10.1158/0008-5472.can-09-2668
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发表时间：
2010-01-01
期刊：
影响因子：
11.2
通讯作者：
Zhu, Zhenglun
中科院分区：
文献类型：
--
作者：
Gao, Hong;Le, Yi;Zhu, Zhenglun
淋巴增强因子/T细胞因子(LEF1/TCF)是一类高迁移率的转录因子，在早期胚胎发育和个体发育过程中起着决定细胞命运的重要作用。LEF1/TCF介导的转录异常激活与多种恶性肿瘤有关。我们最近对脊椎动物胚胎发生的研究发现，XOM是骨形态发生蛋白4途径中的一种同源框蛋白，是一种新的Lef/TCF相关转录调节因子。在这里，我们报道了人类XOM同源物VentX，是典型的Wnt/β-catenin信号的Lef/Tcf相关的抑制物，也是细胞增殖的负调控因子。VentX主要在造血细胞中表达，在慢性淋巴细胞白血病中表达显著下调。VentX的表达改变与Lef/Tcf靶癌基因如细胞周期蛋白D1的相应变化有关，提示VentX在血液系统恶性肿瘤的临床行为中具有潜在的作用。癌症资源；70(1)；202-11。(C)2010年AACR。
Lymphoid-enhancing factor/T-cell factors (LEF1/TCF) are a high-mobility group of transcriptional factors that play essential roles in cell fate determination during early embryogenesis and ontogenesis. Aberrant activations of LEF1/TCF-mediated transcription have been implicated in a variety of malignancies. Our recent studies on vertebrate embryogenesis identified Xom, a homeobox protein of the bone morphogenetic protein 4 pathway, as a novel LEF/TCF-associated transcriptional modulator. Here, we report that VentX, a human Xom homologue, is a LEF/TCF-associated inhibitor of canonical Wnt/beta-catenin signaling and a negative regulator of cell proliferation. VentX is predominately expressed in hematopoietic cells, and its expression is significantly downregulated in chronic lymphocytic leukemia. Altered expression of VentX is associated with corresponding changes of LEF/TCF target oncogenes such as cyclin D1, suggesting a potential role of VentX in the clinical behavior of hematopoietic malignancies. Cancer Res; 70( 1); 202-11. (C)2010 AACR.