DIFFERENTIAL ACTIVITY OF MATERNALLY AND PATERNALLY DERIVED CHROMOSOME REGIONS IN MICE
DIFFERENTIAL ACTIVITY OF MATERNALLY AND PATERNALLY DERIVED CHROMOSOME REGIONS IN MICE
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DOI：
10.1038/315496a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
KIRK, M
中科院分区：
文献类型：
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作者：
CATTANACH, BM;KIRK, M
虽然双亲的两性都对受精卵提供了相同的遗传信息，但在哺乳动物中，这种信息在功能上不一定相同。具有两个母本基因组的二倍体单性生殖体通常是不存活的1，人类中具有两个父本基因组的胚胎可能形成葡萄胎2，小鼠的核移植实验表明，两个亲本基因组对于完整的胚胎发生是必需的3 -6。然而，并非所有的基因组都参与了这些亲本效应，因为小鼠染色体1、4、5、9、13、14和15具有母本或父本二体性的受精卵可以正常存活7，8。另一方面，只有母体X染色体在小鼠胚外膜中是活跃的9，母体6号二体是致死的7，而已经认识到2号、8号和17号染色体区域的母体重复/父体缺陷或其倒数的非互补10 -12。我们报告说，动物与母亲的重复/父亲的缺陷和它的倒数的两个特定的染色体区域显示异常的表型，从正常的方向相反，这表明在这些区域内的基因位点的差异功能。还报道了非互补致死性的另一个实例。
Although both parental sexes contribute equivalent genetic information to the zygote, in mammals this information is not necessarily functionally equivalent. Diploid parthenotes possessing two maternal genomes are generally inviable1, embryos possessing two paternal genomes in man may form hydatidiform moles2, and nuclear transplantation experiments in mice have shown that both parental genomes are necessary for complete embryogenesis3–6. Not all of the genome is involved in these parental effects, however, because zygotes with maternal or paternal disomy for chromosomes 1, 4, 5, 9, 13, 14 and 15 of the mouse survive normally7,8. On the other hand, only the maternal X chromosome is active in mouse extraembryonic membranes9, maternal disomy 6 is lethal7, while non-complementation of maternal duplication/paternal deficiency or its reciprocal for regions of chromosome 2, 8 and 17 has been recognized10–12. We report that animals with maternal duplication/paternal deficiency and its reciprocal for each of two particular chromosome regions show anomalous phenotypes which depart from normal in opposite directions, suggesting a differential functioning of gene loci within these regions. A further example of non-complementation lethality is also reported.