The survival effect of E-cadherin and catenins in colorectal carcinomas
The survival effect of E-cadherin and catenins in colorectal carcinomas
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DOI：
10.1111/j.1463-1318.2009.01994.x
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发表时间：
2010-12-01
影响因子：
3.4
通讯作者：
Akin, M. L.
中科院分区：
文献类型：
--
作者：
Filiz, A. I.;Senol, Z.;Akin, M. L.
目的E-钙粘蛋白/连环蛋白复合体在上皮组织结构中起重要作用。据报道，细胞黏附分子(E-钙粘蛋白、α-连环蛋白、β-连环蛋白和γ-连环蛋白)的表达减少与侵袭行为有关。方法采用免疫组织化学方法检测138例结直肠癌组织中黏附分子的表达。结果患者年龄21~89岁，平均65岁。在原发癌中，E-钙粘附素、α-连环素、β-连环素、γ-连环素的膜表达降低(分别为70%、68%、73%、77%)。8例(5%)患者有β-连环蛋白的核表达。膜上β-连环蛋白和γ-连环蛋白表达降低与肿瘤分化程度显著相关(P=0.013.0 5，P=0.0 3)。晚期肿瘤与膜型α-连环蛋白表达降低有显著相关性(P=0.012)。E-钙粘附素和β-连环素的膜表达降低与术后生存期短相关(P=0.04，P=0.03)。结论E-钙粘附素和β-连环素的膜表达降低和胞浆表达增加可作为监测结直肠癌患者预后的指标。
Aim The E-cadherin/catenin complex plays an important role in epithelial tissue architecture. Decreased expression of cell adhesion molecules (E-cadherin, alpha-, beta- and gamma-catenin) have been reported to correlate with invasive behaviour. The aim of this study was to investigate the relation between the expression of adhesion molecules and clinicopathological characteristics and survival in colorectal carcinoma.Method The expression of adhesion molecules were studied by immunohistochemistry in 138 colorectal carcinomas.Results The mean age of the patients was 65 years (range: 21-89 years). In primary carcinomas, a reduction in membranous expression of E-cadherin, alpha-catenin, beta-catenin, gamma-catenin was demonstrated (70%, 68%, 73%, 77%, respectively). Nuclear expression of beta-catenin was found in eight (5%) patients. Decreased membranous beta-and gamma-catenin expression significantly correlated with tumour differentiation (P = 0.013, P = 0.03, respectively). There was a significant association between advanced stage of the tumour and decreased membranous alpha-catenin expression (P = 0.012). Decreased E-cadherin and beta-catenin membranous expression correlated with short survival following curative resection of the primary tumour (P = 0.04, P = 0.03, respectively).Conclusion The decreased membranous expression of E-cadherin and beta-catenin and increased cytoplasmic expression of beta-catenin might be used as a prognostic marker to monitor patients with colorectal cancer.