A genetic analysis of male-predominant pheromones in Drosophila melanogaster.
A genetic analysis of male-predominant pheromones in Drosophila melanogaster.
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果蝇雄性主导信息素的遗传分析。
DOI：
10.1093/genetics/119.3.639
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发表时间：
1988
期刊：
影响因子：
3.3
通讯作者：
Richmond,RC
中科院分区：
文献类型：
--
作者：
Scott,D;Richmond,RC
来自雄性的化学信号在刺激雌性黑腹果蝇交配方面发挥着重要作用，而雄性占主导地位的信息素可能会影响雌性果蝇的择偶选择。男性主导的信息素也会抑制求爱，从而起到抗春药的作用。两种雄性占主导地位的信息素（7-三碳烯和7-五碳烯）比例的种间变异已被报道，但这种潜在重要变异的遗传基础尚未得到检验。在一系列 7-二十碳烯和 7-五碳烯含量差异很大的菌株之间的杂交中，我们发现了 X 连锁和常染色体对这些化合物含量的菌株间变异的贡献。 X连锁基因座充当增强子，用于产生X染色体起源的菌株中占优势的化合物。这两种化合物的常染色体因子似乎分为高与低，高 7-二十碳烯相对于低 7-二十碳烯不完全占优势，而低 7-五碳烯相对于高 7-五碳烯不完全占优势。 F2 和回交后代中的 7-五碳烯和 7-三碳烯的数量之间存在显着的负相关性，但在 F1 或亲代中则不然，这表明调节每种化合物表达的常染色体基因座之间的联系。然而，回交后代的表型分布表明，额外的未连锁基因座也直接参与这两种碳氢化合物的生产。
Chemical signals from males play an important role in stimulating Drosophila melanogaster females to mate, and male-predominant pheromones may influence a female's choice of mates. Male-predominant pheromones also inhibit courtship, thereby functioning as antiaphrodisiacs. Interstrain variation in the ratio of two male-predominant pheromones (7-tricosene and 7-pentacosene) has been reported, but the genetic basis for this potentially important variation has not been examined. In a series of crosses between strains that differ radically in the amounts of 7-tricosene and 7-pentacosene, we have identified both X-linked and autosomal contributions to interstrain variation in the amounts of these compounds. The X-linked loci act as enhancers for production of the compound predominant in the strain from which the X chromosome originated. Autosomal factors for each of the two compounds appear to segregate as high vs. low, with incomplete dominance of high 7-tricosene over low, and low 7-pentacosene over high. A significant negative correlation between the quantities of 7-pentacosene and 7-tricosene in the F2 and backcross progeny, but not in the F1s or parentals, indicates linkage between autosomal loci regulating the expression of each compound. However, the phenotypic distributions of the backcross progeny indicate that additional unlinked loci are also directly involved in the production of these two hydrocarbons.