Operant model of frustrated expected reward in mice
Operant model of frustrated expected reward in mice
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DOI：
10.1111/j.1369-1600.2011.00423.x
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发表时间：
2012-07-01
影响因子：
3.4
通讯作者：
Maldonado, Rafael
中科院分区：
文献类型：
--
作者：
Burokas, Aurelijus;Gutierrez-Cuesta, Javier;Maldonado, Rafael
成瘾过程的一个方面还没有得到彻底的调查，那就是当药物不可用时出现的沮丧状态的后果。本研究旨在验证一种新的小鼠期望奖赏受挫操作模型。C57BL/6J小鼠接受由巧克力味颗粒或可卡因维持的操作性条件反射训练。在按累进比率时间表完成高回应率后，奖励出人意料地被扣留。研究了这种令人沮丧的行为对焦虑、攻击性、毅力、灭绝和恢复的影响。暴露在受挫事件中的小鼠在操作型反应中坚持下来，并在常驻入侵者测试中表现出更强的攻击性。这些动物也表现出更高的线索诱导恢复药物寻找的比率。本研究提供了一种可靠的小鼠操作模型来评估奖赏不可得后的受挫状态。这种动物模型可能有助于研究行为和神经化学后果，这些后果与遗漏期望很高的奖励时产生的情绪状态有关。
One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice. C57BL/6J mice were trained in operant conditioning maintained by chocolate-flavoured pellets or cocaine. After the completion of high rates of responding on a progressive ratio schedule, the reward was unexpectedly withheld. The consequences of this frustrated behaviour on anxiety, aggressiveness, perseveration, extinction and reinstatement were investigated. Mice exposed to the frustrated event perseverated in the operant responses and showed increased aggressiveness in the residentintruder test. These animals also showed higher rates of cue-induced reinstatement of drug seeking. The present study provides a reliable operant model in mice to evaluate a frustrated state following reward unavailability. This animal model could be useful to study the behavioural and neurochemical consequences related to the emotional states generated during the omission of a highly expected reward.