Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents.
Prodrugs of thyrotropin-releasing hormone and related peptides as central nervous system agents.
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DOI：
10.3390/molecules14020633
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发表时间：
2009-02-06
期刊：
影响因子：
--
通讯作者：
Prokai L
中科院分区：
文献类型：
--
作者：
Prokai-Tatrai K;Prokai L
Prodrug design for brain delivery of small- and medium-sized neuropeptides was reviewed, focusing on thyrotropin-releasing hormone and structurally related peptides as examples. We have summarized our most important advances in methodology, as well as assessed the benefits and limitations of bioreversible chemical manipulation techniques to achieve targeting of the parent molecules into the central nervous system. The value of prodrug-amenable analogues as potential drug-like central nervous systems agents was highlighted.
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