A brief and subjective history of contractility.
A brief and subjective history of contractility.
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收缩性的简要和主观历史。
DOI：
10.1002/pro.5560040116
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Morales,MF
中科院分区：
文献类型：
--
作者：
Morales,MF
回顾自己的职业生涯，以便为回忆录写作，这对作者来说是一种非常感人的经历（就像据说在溺水的过程中发生的事情一样），但是要让读者对这样的评论感兴趣，需要添加一些东西。我试图在我的佐贺中编织的是我对我的领域是如何发展的个人看法，在大学期间的某个时候，我得出结论，科学上的“成就”包括对一个重要现象的研究，研究得足够好，足以用数学形式主义表明，所发生的事情正是人们将大定律应用于所研究的系统所期望的。在完成研究生学业，经历了一场战争，并在一所伟大的大学找到了工作之后，我开始了我的探索，似乎只需要选择一个重要的现象。这一现象被证明是生物收缩性的--回想起来，这是一个很好的选择，但是，在当时，这纯粹是一个偶然的结果。这一年是1946年，也就是说，在这次评估之前的48年。在社会科学中，肯定“每个人都站在别人的肩膀上”是博学的，并以这种方式追溯到巴比伦或玛雅作家，但在我的探索中，只有两个以前的贡献真正重要。七年前，弗吉尼亚州恩格尔哈特和他的妻子卢比莫娃从肌肉中提取了一种蛋白质，“肌球蛋白”，并表明当这种蛋白质被拉成细丝并提供酶底物ATP时，随着ATP的消耗，细丝的机械特性发生了变化。几年后，Albert Szent-Gyorgyi和他的同事Straub发现，“肌球蛋白”是两种蛋白质的复合物--真正的肌球蛋白（ATP酶）和一种重要的伴侣蛋白，他们将其命名为肌动蛋白。也许我应该承认现在我们
Reviewing one’s career in order to write for Recollections is a very moving experience for an author (rather like what is said to happen in the process of drowning), but interesting a reader in such a review requires adding something. What I have tried to weave into my saga is a personal view of how my field has developed.Sometime during the course of my university years, I concluded that “achievement” in science consists of studying a significant phenomenon well enough to show in mathematical formalism that what happens is just what one expects from applying the Great Laws to the system under study. After completing graduate school, experiencing a war, and obtaining employment at a great university, beginning my quest seemed to require only the selection of a significant phenomenon. The phenomenon turned out to be biological contractility-in retrospect a good choice, but, at the time, one reached by pure accident. The year was 1946, that is, 48 years before this assessment. In socio-science, it is erudite to affirm that “everyone stands on the shoulders of someone else,” and in this way work back to Babylonian or Mayan authors, but in my quest only two previous contributions really mattered. Seven years before, VA Engelhardt and this wife, Lubimova, extracted from muscle the protein,“myosin,” and showed that when this protein was drawn into threads and supplied with the enzymatic substrate, ATP, the mechanical properties of the threads changed as the ATP was consumed. A few years later, Albert Szent-Gyorgyi and his associate, Straub, showed that “myosin” was a complex of two proteins-real myosin (the ATPase) and an essential partner protein that they named actin. Perhaps I should admit that now we