Palladium catalyzed alkylation with allylic acetates under neutral conditions
Palladium catalyzed alkylation with allylic acetates under neutral conditions
复制标题
DOI：
10.1021/jo981599c
复制
发表时间：
1998-12-25
影响因子：
3.6
通讯作者：
Poli, G
中科院分区：
文献类型：
--
作者：
Giambastiani, G;Poli, G
钯催化的软亲核试剂的烯丙基烷基化是最有用的有机转化之一。在我们最近对活化羧酰胺的钯催化分子内烯丙基烷基化的研究中，我们注意到即使在没有烯醇化系统 BSA/AcOK (cat.) 的情况下，也可以有趣地获得少量环化产物。为了阐明这个有趣的结果，我们决定在 BSA/AcOK 猫存在的情况下检查简单的分子间反应。 （方法 A）或在无碱条件下（方法 B）（方案 1）。
The palladium catalyzed allylic alkylation of soft nucleophiles represents one of the most useful organic transformations. During our recent studies in palladium-catalyzed intramolecular allylic alkylations of activated carboxamides, we noticed that small amounts of cyclization product could be intriguingly attained even in the absence of the enolizating system BSA/AcOK (cat.). In order to shed light on this intriguing result, we decided to examine simple intermolecular reactions either in the presence of BSA/AcOK cat. (method A) or under base-free conditions (method B) (Scheme 1).