Polymorphism in carbamazepine cocrystals
Polymorphism in carbamazepine cocrystals
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DOI：
10.1021/cg701022e
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发表时间：
2008-01-01
影响因子：
3.8
通讯作者：
Matzger, Adam J.
中科院分区：
文献类型：
--
作者：
Porter, William W., III;Elie, Sophia C.;Matzger, Adam J.
卡马西平与烟酰胺和糖精的共晶体显示出多晶型。卡马西平-烟酰胺（CBZ-NCT）共晶的两种多晶型物和卡马西平-糖精（CBZ-SAC）共晶的两种多晶型物在聚合物异核存在下从溶液中生长。通过拉曼光谱和粉末 X 射线衍射对两种 CBZ-NCT 多晶型物 CBZ-NCT I 和 CBZ-NCT 的聚合物成核 (PN) 形式进行了表征。 CBZ-SAC 11 是一种新的多晶型物，被发现属于单斜空间群 C2/c，a = 35.72 埃，b = 6.84 埃，c = 16.11 埃，β = 98.03 度。 CBZ-SAC 11 的独特之处在于卡马西平和糖精之间形成异合成体。这些结果值得注意，因为 CBZ-NCT 和 CBZ-SAC 是研究最广泛的药物共晶体之一。
Cocrystals of carbamazepine with nicotinamide and saccharin are shown to be polymorphic. Two polymorphs of carbamazepine-nicotinamide (CBZ-NCT) cocrystals and two polymorphs of carbamazepine-saccharin (CBZ-SAC) cocrystals were grown from solution in the presence of polymer heteronuclei. The two CBZ-NCT polymorphs, CBZ-NCT I and a polymer nucleated (PN) form of CBZ-NCT, were characterized by Raman spectroscopy and powder X-ray diffraction. CBZ-SAC 11, a new polymorph, was found to be in the monoclinic space group C2/c with a = 35.72 angstrom b = 6.84 angstrom, c = 16.11 angstrom, and beta = 98.03 degrees. The unique feature of CBZ-SAC 11 is the formation of a heterosynthon between the carbamazepine and saccharin. These results are notable because CBZ-NCT and CBZ-SAC are among the most widely studied pharmaceutical cocrystals.