Neurological recovery by EEG bursting after resuscitation from cardiac arrest in rats
Neurological recovery by EEG bursting after resuscitation from cardiac arrest in rats
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DOI：
10.1016/s0300-9572(02)00196-x
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发表时间：
2002-11-01
期刊：
影响因子：
6.5
通讯作者：
Hanley, DF
中科院分区：
文献类型：
--
作者：
Geocadin, RG;Sherman, DL;Hanley, DF
导读：心脏骤停（CA）复苏后早期神经功能的恢复还没有系统的评估。我们报告了复苏后极早期脑电图爆发模式的时间分析。设计/方法：根据单一标准：基于神经缺陷评分（NDS）的24小时神经行为功能，从遭受5或7分钟窒息性心脏骤停（ACA）的大鼠群体中选择一组预后良好和预后较差的动物。选取连续6只预后良好大鼠（NDS大于等于60）和连续6只预后不良大鼠（NDS < 60）的脑电图进行研究。将这些动物的脑电图交给两名脑电图检查人员，他们对选择过程、实验条件和神经行为恢复情况一无所知。研究了脑电爆发的频率、峰值和持续时间等特征。结果：预后良好动物脑电图爆发明显增高（P < 0.05），爆发复合体在90 min时演变为持续活动。在预后较差的组中观察到持续存在且未能演变为持续活动的较低频率爆裂。结论：在中度至重度ACA复苏后的前30-40分钟，观察到24小时神经预后良好的大鼠脑电图破裂增加。早期脑电图破裂模式可以提供CA复苏后的额外预测。版权所有。
Introduction: The return of neurological function during the early period after resuscitation from cardiac arrest (CA) has not been evaluated systematically. We report the temporal analysis of EEG bursting pattern during the very early periods after resuscitation. Design/method: A balanced group of good and poor outcome animals was selected from a population of rats subjected to either 5 or 7 min of asphyxial cardiac arrest (ACA) on the basis of a single criteria: 24 h neurobehavioral function based on the neurodeficit score (NDS). The EEGs of six consecutive good outcome rats (NDS greater than or equal to 60) and six consecutive poor outcome rats (NDS < 60) were selected for the study. The EEGs of these animals were given to two EEG examiners who were blinded to the selection process, the experimental conditions and the neurobehavioral recovery. The EEG bursting characteristics, such as rate, peak and duration of bursting were studied. Results: There was significantly higher EEG bursting in the good outcome animals (P < 0.05) and the burst complexes evolved into continuous activity by 90 min. Lower frequency bursting that persisted and failed to evolve into continuous activity was observed in the poor outcome group. Conclusion: Increased EEG bursting during first 30-40 min after resuscitation from moderate to severe ACA was observed in rats with good neurological outcome at 24 h. Early EEG bursting patterns may provide additional prognostication after resuscitation from CA. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.