Microfluidics-generated pancreatic islet microfibers for enhanced immunoprotection
Microfluidics-generated pancreatic islet microfibers for enhanced immunoprotection
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DOI：
10.1016/j.biomaterials.2013.07.079
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发表时间：
2013-11-01
期刊：
影响因子：
14
通讯作者：
Lee, Dong Yun
中科院分区：
文献类型：
--
作者：
Jun, Yesl;Kim, Min Jun;Lee, Dong Yun
胰岛移植是治疗1型糖尿病的一种很有前途的方法。然而，移植的胰岛可能由于宿主免疫反应而被破坏。为了免疫保护移植的胰岛，这里新设计了通过使用基于聚二甲基硅氧烷（PDMS）的微流体装置的包括胰岛的免疫保护微纤维。微流控平台中的圆柱形流动通道用于生产胶原-藻酸盐复合物（CAC）纤维。这使得批量生产和均匀的直径分布（
Pancreatic islet transplantation is a promising method for treatment of type 1 diabetes mellitus. However, transplanted islets can be destroyed due to host immune reactions. To immunologically protect transplanted islets, here an immunoprotective microfiber including islets by using a polydimethylsiloxane (PDMS)-based microfluidic device is newly designed. A cylindrical-flow channel in the microfluidic platform is used for producing collagen-alginate composite (CAC) fibers. This enables mass production and uniform diameter distribution (