Serologic evidence of exposure to influenza D virus among persons with occupational contact with cattle
Serologic evidence of exposure to influenza D virus among persons with occupational contact with cattle
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DOI：
10.1016/j.jcv.2016.05.017
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发表时间：
2016-08-01
影响因子：
8.8
通讯作者：
Lednicky, John A.
中科院分区：
文献类型：
--
作者：
White, Sarah K.;Ma, Wenjun;Lednicky, John A.
背景资料：D型流感病毒（Influenza D virus，IDV）是一种新的流感病毒，其分类为正粘病毒科，流感病毒属，流感病毒种，与牛和猪的流感样疾病有关。最近，在小型反刍动物中也检测到抗IDV抗体。一般人群的血清阳性率估计约为1.3%。目的：了解IDV对佛罗里达中北部职业性接触牛的成人的人畜共患潜力。研究：对35名接触牛和11名未接触牛的成年人的人血清样本进行了横断面血清学研究，以使用血凝抑制（HI）筛查IDV抗体结果：在佛罗里达州从事牛工作的人群中，用HI法检测血清阳性率为91%，用MN法检测血清阳性率为97%。在非牛暴露的个人，血清阳性测定通过MN试验（仅）是较低的（18%）。结论：IDV构成了人畜共患病的风险，牛暴露的工人，根据检测高血清阳性率（94-97%）。虽然IDV是否会引起人类疾病仍然是未知的，但我们的研究表明，该病毒可能是养牛工人中的一种新兴病原体。(C)© 2016 Elsevier B. V.版权所有。
Background: Influenza D virus (IDV), a novel influenza virus with proposed classification: family Orthomyxoviridae, genus Influenzavirus D, species Influenza D virus, has been associated with influenza-like illness in cattle and swine. More recently, anti-IDV antibodies have also been detected in small ruminants. A seroprevalence of approximately 1.3% has been estimated for the general human population.Objectives: To gain insights on the zoonotic potential of IDV to human adults with occupational exposure to cattle in north central Florida.Study: A cross-sectional serological study was performed on human serum samples from 35 cattle-exposed and 11 non-cattle-exposed adults to screen for IDV antibodies using hemagglutination inhibition (HI) and microneutralization (MN) assays.Results: A seroprevalence of 91% was detected via HI assay, and 97% by MN assay among individuals working with cattle in Florida. Among non-cattle-exposed individuals, seropositivity determined via MN assay (only) was lower (18%).Conclusions: IDV poses a zoonotic risk to cattle-exposed workers, based on detection of high seroprevalence (94-97%). Whereas it is still unknown whether IDV causes disease in humans, our studies indicate that the virus may be an emerging pathogen among cattle-workers. (C) 2016 Elsevier B.V. All rights reserved.