Plasma glucose and insulin concentrations after implantation and surgical resection of a transplantable rat insulinoma
Plasma glucose and insulin concentrations after implantation and surgical resection of a transplantable rat insulinoma
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可移植大鼠胰岛素瘤植入和手术切除后的血浆葡萄糖和胰岛素浓度
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
J. D. Webster
中科院分区：
文献类型：
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作者：
P. Flatt;K. Tan;C. Bailey;S. Swanston;V. Marks;J. D. Webster
尽管在过去十年中，关于胰岛b细胞肿瘤患者的诊断、治疗和管理取得了重大进展（Frerichs & Creutzfeldt, 1976; Anonymous, 1981; Marks & Rose, 1981），但关于这种缺陷的基本性质和胰岛素分泌肿瘤（胰岛素瘤）对新陈代谢的一般影响，仍有许多有待了解的地方。为了回答这些问题，人们关注于开发一种适合更详细和彻底研究的动物模型（Baba et al., 1979; Creutzfeldt eta .）。, 1980)。用于肿瘤诱导的方法多种多样，从施用化学物质到暴露于电离辐射。尽管成功率很低，但已经诱导了许多具有广泛不同特征的胰岛细胞肿瘤（Baba et al., 1979; Creutzfeldt et al., 1980）。然而，很少有肿瘤适合连续移植繁殖（Chick et al., 1980）。本报告描述了移植大鼠胰岛素瘤植入和手术切除后的血浆葡萄糖和胰岛素浓度。最初的肿瘤是几年前由x射线照射诱发的（Chick et al., 1977）。自那以后，它已被采用为一种方便的替代来源的大量
Although significant advances have been made during the past decade concerning the diagnosis, treatment and management of patients with an islet B-cell tumour (Frerichs & Creutzfeldt, 1976; Anonymous, 1981; Marks & Rose, 1981), much remains to be learnt about the basic nature of the defect and the general effects of insulin-secreting tumours (insulinomas) on metaolism. To answer these questions, attention has been given to the development of an animal model suitable for more detailed and thorough investigation (Baba et al., 1979; Creutzfeldt et a[., 1980). Various approaches have been used for tumour induction, ranging from the administration of chemicals to exposure to ionizing radiations. Despite the low success rate, numerous islet-cell tumours with widely different characteristics have been induced (Baba et al., 1979; Creutzfeldt et al., 1980). However, few tumours have been found to be suitable for propagation by serial transplantation (Chick et al., 1980). The present report describes plasma glucose and insulin concentrations after implantation and surgical resection of a transplantable rat insulinoma. The original tumour was induced several years ago by X-ray irradiation (Chick et al., 1977). It has since been adopted as a convenient alternative source of large amounts of