Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow.
Paravascular spaces at the brain surface: Low resistance pathways for cerebrospinal fluid flow.
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DOI：
10.1177/0271678x17737984
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Bakker EN
中科院分区：
文献类型：
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作者：
Bedussi B;Almasian M;de Vos J;VanBavel E;Bakker EN
从大脑中清除废物是至关重要的。最近的出版物表明，通过血管周围的血管旁通道的潜在清除机制。动脉搏动可能为血管旁血流提供驱动力，但其血流模式仍不清楚。此外，软脑膜血管周围的血管旁血流与穿通血管之间的关系尚不清楚。在这项研究中，我们通过变薄的颅骨颅窗确定了血流和直径脉动。我们观察到微球优先在动脉的血管旁空间移动，而不是在邻近的蛛网膜下腔或静脉周围。血管旁血流是脉动性的，由心动周期产生，具有净顺行血流。共聚焦成像显示微球沿着软脑膜动脉分布，而它们的存在沿着穿通动脉仅限于少数血管。这些数据表明，软脑膜动脉周围的血管旁间隙在脑表面形成低阻力通路，促进脑脊液流动。
Clearance of waste products from the brain is of vital importance. Recent publications suggest a potential clearance mechanism via paravascular channels around blood vessels. Arterial pulsations might provide the driving force for paravascular flow, but its flow pattern remains poorly characterized. In addition, the relationship between paravascular flow around leptomeningeal vessels and penetrating vessels is unclear. In this study, we determined blood flow and diameter pulsations through a thinned-skull cranial window. We observed that microspheres moved preferentially in the paravascular space of arteries rather than in the adjacent subarachnoid space or around veins. Paravascular flow was pulsatile, generated by the cardiac cycle, with net antegrade flow. Confocal imaging showed microspheres distributed along leptomeningeal arteries, while their presence along penetrating arteries was limited to few vessels. These data suggest that paravascular spaces around leptomeningeal arteries form low resistance pathways on the surface of the brain that facilitate cerebrospinal fluid flow.