Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment.
Mesenchymal Stem Cells: Cell Fate Decision to Osteoblast or Adipocyte and Application in Osteoporosis Treatment.
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间充质干细胞：成骨细胞或脂肪细胞的细胞命运决定及其在骨质疏松症治疗中的应用
DOI：
10.3390/ijms19020360
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发表时间：
2018-01-25
影响因子：
5.6
通讯作者：
Qian A
中科院分区：
文献类型：
--
作者：
Hu L;Yin C;Zhao F;Ali A;Ma J;Qian A
骨质疏松症是一种进行性骨骼疾病，其特征是骨量减少，骨微结构退化，导致骨脆性增加，骨折的风险增加。骨质疏松症一般与年龄有关，已成为世界上的一大疾病。揭示骨质疏松症的分子机制，开发有效的防治方法，对人类健康具有重要意义。间充质干细胞(MSCs)是一种能分化为成骨细胞、脂肪细胞或软骨细胞的多能细胞，已成为细胞治疗的首选来源。有证据表明，在骨质疏松的过程中，MSCs的细胞分化向脂肪细胞而不是成骨细胞的转变是导致骨质疏松的部分原因。因此，揭示骨髓间充质干细胞向成骨细胞或脂肪细胞分化的分子机制将有助于更多地了解骨髓间充质干细胞，并可能为治疗骨质疏松症提供新的方法。骨髓间充质干细胞已被应用于骨质疏松症的临床前和临床研究。本文就近年来对MSCs成骨细胞分化和脂肪细胞分化调控分子机制的研究进展作一综述，并重点介绍MSCs在骨质疏松治疗中的应用研究。这将为研究人员对骨质疏松症的发展和治疗提供新的见解。
Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and degraded bone microstructure, which leads to increased bone fragility and risks of bone fracture. Osteoporosis is generally age related and has become a major disease of the world. Uncovering the molecular mechanisms underlying osteoporosis and developing effective prevention and therapy methods has great significance for human health. Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiating into osteoblasts, adipocytes, or chondrocytes, and have become the favorite source of cell-based therapy. Evidence shows that during osteoporosis, a shift of the cell differentiation of MSCs to adipocytes rather than osteoblasts partly contributes to osteoporosis. Thus, uncovering the molecular mechanisms of the osteoblast or adipocyte differentiation of MSCs will provide more understanding of MSCs and perhaps new methods of osteoporosis treatment. The MSCs have been applied to both preclinical and clinical studies in osteoporosis treatment. Here, we review the recent advances in understanding the molecular mechanisms regulating osteoblast differentiation and adipocyte differentiation of MSCs and highlight the therapeutic application studies of MSCs in osteoporosis treatment. This will provide researchers with new insights into the development and treatment of osteoporosis.
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影响因子：
4.1
作者：
Cawthorn WP;Bree AJ;Yao Y;Du B;Hemati N;Martinez-Santibañez G;MacDougald OA
通讯作者：
MacDougald OA
影响因子：
4
作者：
Astudillo, Pablo;Rios, Susana;Rodriguez, J. Pablo
通讯作者：
Rodriguez, J. Pablo
影响因子：
11.8
作者：
Bialek, P;Kern, B;Karsenty, G
通讯作者：
Karsenty, G
影响因子：
4.1
作者：
Cho, Sun Wook;Sun, Hyun Jin;Shin, Chan Soo
通讯作者：
Shin, Chan Soo
影响因子：
5.7
作者：
Carroll SF;Buckley CT;Kelly DJ
通讯作者：
Kelly DJ