Implant placement enhanced by bioactive glass particles of narrow size range.
Implant placement enhanced by bioactive glass particles of narrow size range.
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通过窄尺寸范围的生物活性玻璃颗粒增强植入物的植入。
DOI：
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发表时间：
1998
期刊：
影响因子：
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通讯作者：
P. Ducheyne
中科院分区：
文献类型：
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作者：
E. Schepers;L. Barbier;P. Ducheyne
骨质和骨量差通常与种植体失败有关。合成骨移植物可用于促进骨缺损中新骨的形成。本动物研究的目的是确定植入物放置前，窄尺寸范围（300 - 335微米，Biogran）生物活性玻璃颗粒治疗骨缺损的有效性。在6只比格犬的下颌骨两侧，通过去除牙槽内隔膜以获得大的缺损，立即用生物活性玻璃颗粒填充一侧，从而形成部分无牙区。另一侧留空作为对照。经过4个月的愈合期后，将三个口腔种植体分别放置在玻璃处理区和对照区。在三只狗中，种植体留在龈下3个月后，组织切片。在其余三只犬中，在处死前，植入物与固定部分假体功能性负载7周。两组的定性和定量分析显示，与放置在未处理区域的种植体相比，放置在玻璃处理区域的种植体的界面和距离处的骨组织和重塑活动在统计学上显著更多。相反，在生物活性玻璃填充的缺损中植入种植体不会受到危害。
Poor bone quality and quantity are often related to implant failure. Synthetic bone grafts may be used to enhance the formation of new bone in bone defects. The purpose of this animal study was to determine the efficacy of bioactive glass particles of narrow size range (300 to 335 microns, Biogran) in the treatment of bone defects prior to implant placement. On both sides of the mandible of six beagle dogs, areas of partial edentulousness were created by the removal of the intra-alveolar septa to obtain large defects, instantly filled on one side with bioactive glass particles. The other side was left empty as a control. After a healing period of 4 months, three oral implants each were placed in the glass-treated area and in the control zone. In three dogs, the implants were left subgingival for 3 months after which histologic sections were made. In the remaining three dogs, the implants were functionally loaded with a fixed partial prosthesis for 7 weeks before sacrifice. Qualitative and quantitative analysis of both groups revealed statistically significantly more bone tissue and higher remodeling activity at the interface and at a distance of implants placed in glass-treated areas, compared to implants placed in untreated regions. Implant placement in bioactive glass-filled defects was not jeopardized, on the contrary.