ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA
ADRENOMEDULLIN - A NOVEL HYPOTENSIVE PEPTIDE ISOLATED FROM HUMAN PHEOCHROMOCYTOMA
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DOI：
10.1006/bbrc.1993.1451
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发表时间：
1993-04-30
影响因子：
3.1
通讯作者：
ETO, T
中科院分区：
文献类型：
--
作者：
KITAMURA, K;KANGAWA, K;ETO, T
通过监测血小板 cAMP 的升高活性，在人嗜铬细胞瘤中发现了一种新型降压肽。由于这种肽在正常肾上腺髓质以及由肾上腺髓质产生的嗜铬细胞瘤组织中大量存在，因此将其命名为“肾上腺髓质素”。该肽由52个氨基酸组成，具有1个分子内二硫键，与降钙素基因相关肽有轻微同源性。人们发现它能产生有效且持久的降血压作用。这种肽在血液中以相当大的浓度循环，但在大脑中却没有发现。这些数据表明肾上腺髓质素是一种参与血压控制的新激素。肾上腺髓质素的出现表明可能存在一种新的循环控制系统。
A novel hypotensive peptide was discovered in human pheochromocytoma by monitoring the elevating activity of platelet cAMP. Since this peptide is abundant in normal adrenal medulla as well as in pheochromocytoma tissue arising from adrenal medulla, it was designated "adrenomedullin". The peptide, consisting of 52 amino acids, has one intramolecular disulfide bond and shows slight homology with calcitonin gene related peptide. It was found to elicit a potent and long lasting hypotensive effect. The peptide circulates in blood in a considerable concentration, but it was not found in brain. These data suggest that adrenomedullin is a new hormone participating in blood pressure control. Occurrence of adrenomedullin indicates the possible existence of a novel system for circulation control.