A double dose of levocetirizine leads to better control of histamine-induced flare, wheal and itch in healthy donors.
A double dose of levocetirizine leads to better control of histamine-induced flare, wheal and itch in healthy donors.
复制标题
双倍剂量的左西替利嗪可以更好地控制健康供体中组胺引起的红肿、风团和瘙痒。
DOI：
10.1159/000353191
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
et al.
中科院分区：
文献类型：
--
作者：
Tanizaki H;Nakamizo S;et al.
左西替利嗪被归类为非镇静的第二代抗组胺药。这种药是用来治疗过敏性疾病，如荨麻疹和瘙痒。到目前为止，研究表明增加抗组胺药的剂量可以增加治疗难治性荨麻疹的疗效；然而，这些指导方针需要更多的支持性证据来证明这种管理策略的合理性。在这项研究中，我们发现双剂量左西替利嗪与常规剂量相比，在无创方式下使用视觉和激光多普勒成像量表更快速和持续地抑制组胺诱导的耀斑形成，更广泛地抑制轮状和瘙痒。这些结果表明，双剂量左西替利嗪治疗比常规剂量左西替利嗪治疗更迅速、更深刻、更持久地抑制组胺诱导的皮肤症状。
Levocetirizine is classified as a nonsedating second-generation antihistamine. This drug is used to treat allergic disorders such as urticaria and pruritus. Thus far, studies have demonstrated an increase in efficacy for refractory urticaria by increasing doses of antihistamines; however, more lines of supportive evidence for these guidelines are required to justify this management strategy. In this study, we found that a double dose of levocetirizine suppressed histamine-induced flare formation more rapidly and sustainably, and wheal and itch more extensively, compared with the conventional dose using both visual and laser Doppler imaging scales in a noninvasive manner. These results suggest that double-dosed levocetirizine treatment suppresses histamine-induced skin symptoms more rapidly, profoundly and sustainably than conventionally dosed levocetirizine treatment.