Cathodal transcranial direct current stimulation affects seizures and cognition in fully amygdala-kindled rats
Cathodal transcranial direct current stimulation affects seizures and cognition in fully amygdala-kindled rats
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DOI：
10.1179/1743132813y.0000000170
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发表时间：
2013-07-01
影响因子：
1.9
通讯作者：
Fujiki, Minoru
中科院分区：
文献类型：
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作者：
Kamida, Tohru;Kong, Shiqi;Fujiki, Minoru
这项研究评估了弱经颅直流电刺激（tDCS）（一种新的非侵入性脑刺激技术）对杏仁核点燃的大鼠的影响。在最后一次阴极 tDCS 疗程后一天，测量动物的癫痫发作严重程度，即癫痫发作阶段、放电后持续时间 (ADD) 和 AD 阈值 (ADT)，并与治疗前对照进行比较。此外，在最后一次 tDCS 治疗两天后，还通过水迷宫测试 (WMT) 研究了阴极 tDCS 对认知功能的影响。阴极 tDCS 治疗显着改善了癫痫发作阶段，减少了 ADD，并且在最后一次 tDCS 治疗一天后 ADT 升高。该治疗还显示出 WMT 表现的显着改善。研究结果表明，阴极经颅直流电刺激对杏仁核激发的大鼠具有至少持续一天的抗惊厥后遗症，并对认知能力产生积极影响。
This study evaluated the effects of weak transcranial direct current stimulation (tDCS), a new non-invasive brain stimulation technique, on amygdala-kindled rats. The seizure severity, i.e. seizure stage, afterdischarge duration (ADD), and AD threshold (ADT) in the animals were measured one day after the last cathodal tDCS session, comparing with those of pre-treatment controls. Furthermore, the effects of cathodal tDCS on cognitive function were also studied by a water maze test (WMT) two days after the last tDCS session. Cathodal tDCS treatment significantly improved the seizure stage and decreased ADD together with elevated ADT one day after the last tDCS session. The treatment also showed significant improvement in the performance of WMT. The findings suggest that cathodal tDCS has anticonvulsive aftereffects last at least for one day on the amygdale-kindled rats and positively affects cognitive performance.