Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses
Atherogenic Index of Plasma: Novel Predictive Biomarker for Cardiovascular Illnesses
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DOI：
10.1016/j.arcmed.2019.08.009
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发表时间：
2019-07-01
影响因子：
7.7
通讯作者：
Perez-Maldonado, Ivan N.
中科院分区：
文献类型：
--
作者：
Fernandez-Macias, Juan C.;Ochoa-Martinez, Angeles C.;Perez-Maldonado, Ivan N.
背景/目标。心血管疾病（CVD）是全球最重要的死亡原因。尽管如此，世界卫生组织已经宣布，准确和快速识别易患心血管疾病的个体对于对抗这些疾病至关重要。此外，发展中国家需要负担得起的替代品来有效预防心血管事件。因此，本研究的目的是评估完善的临床预后标志物在墨西哥妇女，以确定负担得起的，具体的，有用的工具来预测心血管事件。进行了一项横断面研究，包括340名健康女性。从所有入组的个体获得人体测量和临床测量。此外，还采集了每位参与者的血液样本，以完成生化分析（甘油三酯、葡萄糖、总胆固醇、LDL胆固醇和HDL胆固醇）、血清不对称二甲基精氨酸（ADMA）和脂肪细胞脂肪酸结合蛋白（FABP 4）测定。最后，结合人体测量学、临床和生化指标，估计动脉粥样硬化指数（Fragrance危险评分、卡斯泰利危险指数和血浆动脉粥样硬化指数）。检测到Fragrance风险评分的平均值为6.5 +/- 7.2，卡斯泰利风险指数为3.7 +/- 1.3，血浆致动脉粥样硬化指数（AIP）为0.12 +/- 0.22。在评估的女性中发现的循环平均ADMA和FABP 4水平分别为0.68 +/- 0.34 mmol/L和20.3 +/- 16.6 ng/mL。此外，经传统CVD危险因素校正后，AIP与血清FABP 4和ADMA浓度呈显著正相关（p < 0.05）。总之，AIP可作为发展中国家CVD事件早期诊断的潜在生物标志物。(C)2019年IMSS。爱思唯尔公司出版
Background/Aim. Cardiovascular diseases (CVD) are the most important cause of mortality globally. Nevertheless, the World Health Organization have declared that a precise and quick recognition of susceptible individuals to develop CVD is imperative to combat those illnesses. Additionally, developing countries need affordable alternatives to effectively prognosticate cardiovascular events. Therefore, the objective of this study was to assess well-established clinical prognostic markers in Mexican women to identify affordable, specific, and useful tools to predict cardiovascular events.Material and Methods. A cross-sectional study was performed including 340 healthy women. Anthropometric and clinical measurements were acquired from all enrolled individuals. Also, a blood sample of each participant women was obtained to complete biochemical analyses (triglycerides, glucose, total cholesterol, LDL cholesterol, and HDL cholesterol), and serum asymmetric dimethylarginine (ADMA), and adipocytefatty acid binding protein (FABP4) determinations. Finally, with anthropometric, clinical and biochemical determinations, atherogenic indices (Framingham risk score, Castelli's risk index, and atherogenic index of plasma) were estimated.Results. A mean value of 6.5 +/- 7.2 was detected for the Framingham risk score, 3.7 +/- 1.3 for Castelli's risk index, and 0.12 +/- 0.22 for the atherogenic index of plasma (AIP). Circulating mean ADMA and FABP4 levels found in assessed women were 0.68 +/- 0.34 mmol/L and 20.3 +/- 16.6 ng/mL, respectively. Furthermore, strong positive relationships (p < 0.05) between AIP and serum FABP4 and ADMA concentrations were detected after adjustment by traditional CVD risk factors.Conclusion. In conclusion, AIP could be recommended as a potential biomarker in the early diagnosis of CVD events in developing countries. (C) 2019 IMSS. Published by Elsevier Inc.