Mechanisms of cell volume regulation and possible nature of the cell volume sensor.
Mechanisms of cell volume regulation and possible nature of the cell volume sensor.
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DOI：
10.1016/s0928-4680(01)00074-8
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发表时间：
2001-12-01
期刊：
影响因子：
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通讯作者：
Orlov, Sergei N.
中科院分区：
文献类型：
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作者：
Mongin, Alexander A.;Orlov, Sergei N.
在动物机体中，细胞体积在许多生理和病理过程中经历动态变化。为了保护自己免受细胞溶解和凋亡，并保持细胞内酶和代谢物的最佳浓度，大多数动物细胞主动调节其体积。在本综述中，我们简要地总结了涉及调节性体积减少（RVD）和调节性体积增加（RVI）的离子转运机制的数据，重点是这个问题的未解决的方面，如：（i）细胞如何感觉到它们的体积变化;（ii）细胞体积改变时产生什么信号;以及（iii）这些信号如何被转移到执行细胞体积调节的离子转运系统。
In animal organisms, cell volume undergoes dynamic changes in many physiological and pathological processes. To protect themselves against lysis and apoptosis and to maintain an optimal concentration of intracellular enzymes and metabolites, most animal cells actively regulate their volume. In the present review, we shortly summarize the data on ion transport mechanisms involved in regulatory volume decrease (RVD) and regulatory volume increase (RVI) with an emphasis on unresolved aspects of this problem such as: (i) how cells sense their volume changes; (ii) what signals are generated upon cell volume alterations; and (iii) how these signals are transferred to the ion transport systems executing cell volume regulation.