Preparation and characterization of forsterite (Mg2SiO4) bioceramics
Preparation and characterization of forsterite (Mg2SiO4) bioceramics
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DOI：
10.1016/j.ceramint.2005.07.021
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发表时间：
2007-01-01
影响因子：
5.2
通讯作者：
Chang, Jiang
中科院分区：
文献类型：
--
作者：
Ni, Siyu;Chou, Lee;Chang, Jiang
以镁橄榄石（Mg 2SiO 4）绿色坯体为原料，在1350-1550 ℃下烧结制备了Mg 2SiO 4陶瓷，研究了其烧结行为和力学性能。结果表明，镁橄榄石陶瓷在1450 ℃热处理8 h后，其抗弯强度和断裂韧性分别达到最佳值（203 MPa和2.4 MPa m（1/2）），均高于现有的羟基磷灰石陶瓷。为了进一步阐明镁橄榄石陶瓷的生物相容性，进行了成骨细胞粘附和增殖实验。在镁橄榄石陶瓷表面观察到了均匀分布的细胞。MTT法检测结果显示，烧结陶瓷表面成骨细胞增殖率在第7天明显高于对照组（p < 0.05）。这些结果表明镁橄榄石陶瓷具有良好的生物相容性和机械性能，可能适合作为骨植入材料的潜在应用。(c)2005 Elsevier Ltd和Techna Group S.r.l. All rights reserved.
Forsterite (Mg2SiO4) ceramics were prepared by sintering the Mg2SiO4 green compacts at 1350-1550 degrees C and the sintering behavior and mechanical properties were examined. The results showed that the optimal bending strength (203 MPa) and fracture toughness (2.4 MPa m(1/2)) of forsterite ceramics were obtained after hot treatment at 1450 degrees C for 8 h, which were higher than those of the currently available hydroxyapatite ceramics. In order to clarify the biocompatibility of the forsterite ceramics, osteoblast adhesion and proliferation experiments were carried out. Well-spread cells were observed on the surface of forsterite ceramics. In addition, MTT tests confirmed that the osteoblast proliferation rate was significantly higher on the surface of the sintered ceramics than on the controls at 7 days (p < 0.05). These findings suggest that forsterite ceramics possess good biocompatibility and mechanical properties and might be suitable for potential application like bone implant material. (c) 2005 Elsevier Ltd and Techna Group S.r.l. All rights reserved.