New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum
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DOI：
10.1016/j.bmcl.2005.03.103
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发表时间：
2005-06-02
影响因子：
2.7
通讯作者：
Ishibashi, M
中科院分区：
文献类型：
--
作者：
Hosoya, T;Yamamoto, Y;Ishibashi, M
从田间采集的粘菌 Lycogala epidendrum 子实体中分离出两种新的双吲哚生物碱，即 6-羟基十字孢菌酮 (1) 和 5,6-二羟基arcyriaflavin A (2)，以及八种已知的双吲哚 (3-10)。这些新化合物的结构是根据光谱数据确定的。化合物 1 和 2 对 HeLa、Jurkat 和长春新碱耐药 KB/VJ300 细胞表现出细胞毒性，并且化合物 1 特别抑制蛋白酪氨酸激酶活性。 (c) 2005 Elsevier Ltd. 保留所有权利。
Two new bisindole alkaloids, 6-hydroxystaurosporinone (1) and 5,6-dihydroxyarcyriaflavin A (2) were isolated from field-collected fruit bodies of a myxomycete Lycogala epidendrum, along with eight known bisindoles (3-10). The structures of these new compounds were determined on the basis of spectroscopic data. Compounds 1 and 2 showed cytotoxicity against HeLa, Jurkat, and vincristine resistant KB/VJ300 cells, and compound 1, particularly, inhibited protein tyrosine kinase activity. (c) 2005 Elsevier Ltd. All rights reserved.